Mabuchi H, Nakahashi H
Department of Internal Medicine and Nephrology, Nishijin Hospital, Kyoto, Japan.
Clin Chim Acta. 1987 Jul 30;167(1):89-96. doi: 10.1016/0009-8981(87)90089-1.
In hemodialyzed patients, the serum albumin concentration determined by the bromcresol purple (BCP) method was lower than that determined by an immunological method. The degree of underestimation appeared to be well correlated to the serum concentration of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a major endogenous ligand substance present in uremic serum. CMPF inhibited in vitro the binding of BCP to serum protein and human serum albumin. Our results suggest that CMPF is a major interferent in the underestimation of the serum albumin concentration by the BCP method in uremia.
在血液透析患者中，用溴甲酚紫（BCP）法测定的血清白蛋白浓度低于用免疫学法测定的浓度。低估程度似乎与尿毒症血清中主要的内源性配体物质3-羧基-4-甲基-5-丙基-2-呋喃丙酸（CMPF）的血清浓度密切相关。CMPF在体外抑制BCP与血清蛋白和人血清白蛋白的结合。我们的结果表明，CMPF是尿毒症患者中BCP法低估血清白蛋白浓度的主要干扰因素。
