Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Center for Clinical Research Dalarna, Falun, Uppsala, Sweden.
Curr Hypertens Rep. 2019 Aug 2;21(9):72. doi: 10.1007/s11906-019-0977-0.
To provide insight into the mechanisms underlying cerebral pathophysiology and to highlight possible methods for evaluation, screening, and surveillance of cerebral complications in preeclampsia.
The pathophysiology of eclampsia remains enigmatic. Animal studies show that the cerebral circulation in pregnancy and preeclampsia might be affected with increased permeability over the blood-brain barrier and altered cerebral blood flow due to impaired cerebral autoregulation. The increased blood pressure cannot be the only underlying cause of eclampsia and cerebral edema, since some cases of eclampsia arise without simultaneous hypertension. Findings from animal studies need to be confirmed in human tissues. Evaluation of brain alterations in preeclampsia and eclampsia is challenging and demands a multidisciplinary collaboration, since no single method can accurately and fully describe how preeclampsia affects the brain. Cerebral complications of preeclampsia are significant factors in maternal morbidity and mortality worldwide. No single method can accurately describe the full picture of how preeclampsia affects the brain vasculature and parenchyma. We recommend an international and multidisciplinary effort not only to overcome the issue of limited sample availability but also to optimize the quality of research.
旨在深入了解子痫前期脑病理生理学的机制，并强调子痫前期中脑并发症的评估、筛选和监测的可能方法。
子痫的病理生理学仍然是一个谜。动物研究表明，妊娠和子痫前期的脑循环可能会受到血脑屏障通透性增加和由于脑自动调节受损而改变的脑血流的影响。血压升高不能成为子痫和脑水肿的唯一潜在原因，因为有些子痫病例没有同时发生高血压。动物研究的结果需要在人体组织中得到证实。评估子痫前期和子痫的脑改变具有挑战性，需要多学科合作，因为没有单一的方法可以准确和全面地描述子痫前期如何影响大脑。子痫前期的脑并发症是全球孕产妇发病率和死亡率的重要因素。没有单一的方法可以准确描述子痫前期如何影响脑血管和实质的全貌。我们建议国际和多学科的努力，不仅要克服样本数量有限的问题，还要优化研究质量。
