Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio-Lackland AFB, Texas.
Wilford Hall Ambulatory Surgical Center, Joint Base San Antonio-Lackland AFB, Texas.
Ann Allergy Asthma Immunol. 2019 Oct;123(4):359-365. doi: 10.1016/j.anai.2019.07.022. Epub 2019 Jul 31.
Pollen food allergy syndrome (PFAS) is a complex syndrome posing a diagnostic and therapeutic challenge. Our objective was to summarize the available literature regarding its prevalence, pathogenesis, diagnosis, and treatment.
A PubMed search was performed to include English language articles with the following search terms: pollen food syndrome, pollen food allergy syndrome, PFAS, oral allergy syndrome, OAS, food anaphylaxis, food components.
Human articles discussing PFAS.
Varying reports have been made of the prevalence of PFAS, ranging from 4.7% to greater than 20% in children and 13% to 58% in adults. Prevalence varies widely by geographic region. PFAS is typically the results of class II food allergens (e.g. sensitized to anaeroallergen, but reaction occurs due to cross reactivity from a food allergen). Commonly these reactions are limited to the oropharynx due to the lability of the proteins causing the reaction. As multiple families of proteins with varying stability cause PFAS, severe systemic reactions are also possible, as anaphylactic shock has been documented in up to 1.7% of reactions.
Pollen food allergy syndrome therefore cannot be dismissed as a benign food allergy, but it needs to be approached individually based on known risk factors.
花粉食物过敏综合征（PFAS）是一种复杂的综合征，具有诊断和治疗方面的挑战性。我们的目的是总结有关其患病率、发病机制、诊断和治疗的现有文献。
进行了 PubMed 检索，纳入了以下搜索词的英文文献：花粉食物综合征、花粉食物过敏综合征、PFAS、口腔过敏综合征、OAS、食物过敏反应、食物成分。
讨论 PFAS 的人类文章。
PFAS 的患病率报告各不相同，儿童为 4.7%至 20%以上，成人 13%至 58%。患病率因地理位置而异。PFAS 通常是 II 类食物过敏原（例如，对厌氧菌过敏，但由于食物过敏原的交叉反应而发生反应）的结果。通常，由于引起反应的蛋白质不稳定，这些反应仅限于口咽部，因为过敏反应的严重程度取决于引起反应的蛋白质的稳定性。由于多种具有不同稳定性的蛋白质家族引起 PFAS，也可能发生严重的全身性反应，因为在多达 1.7%的反应中记录到过敏性休克。
因此，花粉食物过敏综合征不能被视为良性食物过敏，但需要根据已知的危险因素进行个体化处理。
