College of Pharmaceutical Sciences, Southwest University, Chongqing, 400716, China.
Department of Radiology, Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, 400010, China; Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, 400010, China.
Biomaterials. 2019 Oct;219:119379. doi: 10.1016/j.biomaterials.2019.119379. Epub 2019 Jul 27.
Engineering interfacial structure of biomaterials have drawn much attention due to it can improve the diagnostic accuracy and therapy efficacy of nanomedicine, even introducing new moiety to construct theranostic agents. Nanosized magnetic resonance imaging contrast agent holds great promise for the clinical diagnosis of disease, especially tumor and brain disease. Thus, engineering its interfacial structure can form new theranostic platform to achieve effective disease diagnosis and therapy. In this study, we engineered the interfacial structure of typical MRI contrast agent, GdO, to form a new theranostic agent with improved relaxivity for MRI guided synergetic chemodynamic/photothermal therapy. The synthesized Mn doped gadolinium oxide nanoplate exhibit improved T contrast ability due to large amount of efficient paramagnetic metal ions and synergistic enhancement caused by the exposed Mn and Gd cluster. Besides, the introduced Mn element endow this nanomedicine with the Fenton-like ability to generate OH from excess HO in tumor site to achieve chemodynamic therapy (CDT). Furthermore, polydopamine engineered surface allow this nanomedicine with effective photothermal conversion ability to rise local temperature and accelerate the intratumoral Fenton process to achieve synergetic CDT/photothermal therapy (PTT). This work provides new guidance for designing magnetic resonance imaging guided synergetic CDT/PTT to achieve tumor detection and therapy.
由于可以提高纳米医学的诊断准确性和治疗效果，甚至可以引入新的部分来构建治疗药物，因此，工程生物材料的界面结构引起了广泛关注。纳米级磁共振成像造影剂在疾病的临床诊断中具有很大的应用前景，特别是肿瘤和脑部疾病。因此，对其界面结构进行工程设计可以形成新的治疗平台，以实现有效的疾病诊断和治疗。在这项研究中，我们对典型的磁共振成像造影剂 GdO 的界面结构进行了工程设计，形成了一种具有改进弛豫率的新型治疗药物，用于磁共振引导的协同化学动力学/光热治疗。合成的 Mn 掺杂氧化钆纳米板由于大量有效的顺磁金属离子和暴露的 Mn 和 Gd 簇引起的协同增强作用，表现出了改进的 T1 对比能力。此外，引入的 Mn 元素赋予这种纳米药物类 Fenton 样能力，可从肿瘤部位的过量 HO 中生成 OH，从而实现化学动力学治疗（CDT）。此外，聚多巴胺工程化表面使这种纳米药物具有有效的光热转换能力，以升高局部温度并加速肿瘤内的 Fenton 过程，从而实现协同的 CDT/光热治疗（PTT）。这项工作为设计磁共振成像引导的协同 CDT/PTT 以实现肿瘤检测和治疗提供了新的指导。
