消化道癌症中的尿激酶型纤溶酶原激活剂。
The urokinase type of plasminogen activator in cancer of digestive tracts.
作者信息
Nishino N, Aoki K, Tokura Y, Sakaguchi S, Takada Y, Takada A
机构信息
Department of Surgery, Hamamatsu Univ., Sch. Med., Japan.
出版信息
Thromb Res. 1988 May 15;50(4):527-35. doi: 10.1016/0049-3848(88)90201-0.
The amounts of urokinase (UK) antigen and tissue plasminogen activator (t-PA) antigen were determined in plasma, urine and tissues of patients with cancer of digestive tracts. Urinary levels of UK, but not those of t-PA increased in patients with cancer, and generally decreased after the removal of cancer by operation. Urinary UK levels kept increasing in patients with recurrence of cancer or with metastasis into liver or peritoneum. Plasma levels of t-PA, but not those of UK decreased in patients with cancer. When the amounts of UK were compared in cancer tissues and their adjacent normal mucosal layer, cancer tissues always had higher levels of UK, but t-PA levels were same between tumor tissues and normal mucosa. The results suggest that the type of plasminogen activator was UK-type in cancer of digestive tracts.
测定了消化道癌症患者血浆、尿液及组织中的尿激酶（UK）抗原和组织型纤溶酶原激活剂（t-PA）抗原含量。癌症患者尿液中UK水平升高，而t-PA水平未升高，且手术切除癌症后UK水平通常下降。癌症复发或发生肝转移或腹膜转移的患者尿液中UK水平持续升高。癌症患者血浆中t-PA水平下降，而UK水平未下降。当比较癌组织及其相邻正常黏膜层中的UK含量时，癌组织中的UK水平总是更高，但肿瘤组织与正常黏膜之间的t-PA水平相同。结果表明，消化道癌症中纤溶酶原激活剂的类型为UK型。
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