Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, 836 W. Gates Building, Philadelphia, PA 19104, USA.
Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, 3737 Market Street, 8th floor, Philadelphia, PA 19104, USA.
Clin Chest Med. 2019 Sep;40(3):531-544. doi: 10.1016/j.ccm.2019.05.002. Epub 2019 Jul 6.
Sjögren syndrome (SS) is a progressive autoimmune disease characterized by dryness, predominantly of the eyes and mouth, caused by chronic lymphocytic infiltration of the lacrimal and salivary glands. Extraglandular inflammation can lead to systemic manifestations, many of which involve the lungs. Studies in which lung involvement is defined as requiring the presence of respiratory symptoms and either radiograph or pulmonary function test abnormalities quote prevalence estimates of 9% to 22%. The most common lung diseases that occur in relation to SS are airways disease and interstitial lung disease. Evidence-based guidelines to inform treatment recommendations for lung involvement are largely lacking.
干燥综合征（SS）是一种进行性自身免疫性疾病，以眼睛和口腔干燥为主要特征，由泪腺和唾液腺的慢性淋巴细胞浸润引起。外分泌腺炎症可导致全身表现，其中许多涉及肺部。将肺部受累定义为需要存在呼吸症状和 X 线或肺功能测试异常的研究报告的患病率估计值为 9%至 22%。与 SS 相关的最常见肺部疾病是气道疾病和间质性肺疾病。缺乏针对肺部受累提供治疗建议的循证指南。
