区域灰质体积与过去认知衰退相关联的静息-活动节律碎片化。
Regional Gray Matter Volume Links Rest-Activity Rhythm Fragmentation With Past Cognitive Decline.
机构信息
Department of Psychiatry (SFS, AR, and HJA), School of Medicine, University of Pittsburgh, Pittsburgh, PA.
Department of Neurology (LC), School of Medicine, University of Pittsburgh, Pittsburgh, PA.
出版信息
Am J Geriatr Psychiatry. 2020 Feb;28(2):248-251. doi: 10.1016/j.jagp.2019.07.009. Epub 2019 Jul 19.
OBJECTIVES
We examined the extent to which measures of neurodegeneration and cerebrovascular disease explain the rest-activity rhythm (RAR)-cognition link.
METHODS
Seventy participants (mean age at MRI = 86, standard deviation (SD) = 2.6; 53% female) had cognitive, MRI, and accelerometer data. The slope of cognitive decline was defined applying a mixed model to 10 repeated Modified Mini Mental Status Test (3MS) measures over 14 years. Regional gray matter volume (GMV), white matter hyperintensities, and RARs were measured around year 12.
RESULTS
Past 3MS decline was related to RAR fragmentation (per SD β = -0.43, 95% confidence interval: -0.73, -0.14) and lower posterior parietal GMV (per standard deviation β = 0.47, 95% confidence interval: 0.14, 0.79). Higher RAR fragmentation was related to lower posterior parietal GMV (Pearson r = -0.39, n = 70, p = 0.0007), which attenuated the association of RAR fragmentation and past cognitive decline by 17%.
CONCLUSIONS
Longitudinal studies are warranted to understand the temporal relations and mechanisms linking RAR fragmentation and neurodegeneration.
目的
我们研究了神经退行性变和脑血管疾病的测量指标在多大程度上解释了静息-活动节律（RAR）与认知之间的关联。
方法
70 名参与者（MRI 时的平均年龄为 86 岁，标准差为 2.6；53%为女性）具有认知、MRI 和加速度计数据。采用混合模型对 10 次重复的改良 Mini 精神状态测试（3MS）在 14 年内的测量值进行分析，定义认知下降的斜率。在大约 12 年时测量了区域灰质体积（GMV）、白质高信号和 RAR。
结果
过去的 3MS 下降与 RAR 碎片化（每标准差β=-0.43，95%置信区间：-0.73，-0.14）和后顶叶 GMV 降低（每标准差β=0.47，95%置信区间：0.14，0.79）有关。较高的 RAR 碎片化与后顶叶 GMV 降低有关（Pearson r = -0.39，n=70，p=0.0007），这使 RAR 碎片化与过去认知下降之间的关联降低了 17%。
结论
需要进行纵向研究，以了解 RAR 碎片化和神经退行性变之间的时间关系和机制。
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