Whitmore Katie M, Buzon Michele R
Department of Anthropology, Purdue University, 700 W. State Street, Suite 219, West Lafayette, IN 47907, USA.
Int J Paleopathol. 2019 Sep;26:135-144. doi: 10.1016/j.ijpp.2019.07.006. Epub 2019 Aug 1.
This project investigates two cases of skeletal dysplasia from archaeological excavations of the New Kingdom Period (c. 1400-1050 BCE) portion of the Tombos cemetery in Sudan.
Fair to well-preserved skeletal remains of two individuals, one adult and one juvenile, are examined here.
All available skeletal elements were analyzed macroscopically. A differential diagnosis was conducted for each individual.
The adult individual, U36.Sh2.B10, displays bilateral mesomelic dysplasia and Madelung's deformity. The juvenile individual, U36.Sh2.B5, also displays bilateral mesomelic dysplasia and characteristics associated with Madelung's deformity.
A differential diagnosis of Léri-Weill dyschondrosteosis (LWD) is suggested for the adult female individual (U36.Sh2.B10). The second case (U36.Sh2.B5) is an approximately three to five-year-old individual and is difficult to diagnose given the young age; however, LWD remains the most likely diagnosis.
There are few cases of LWD in the paleopathological literature, and fewer still of juveniles. The cases described are useful examples in expanding research demonstrating the variability in the expression of skeletal dysplasias in juveniles and adults.
Taphonomic alterations and fragmentation of the crania and portions of the postcrania limited the observation of the full suite of characteristics associated with skeletal dysplasias. U36.Sh2.B5 is difficult to diagnose given the individual's young age and the possibility that this individual had not yet developed the more observable characteristics associated with these conditions.
Researchers are encouraged to continue examining the range of expression of skeletal dysplasias in juveniles and adults.
本项目对苏丹通布索墓地新王国时期（约公元前1400 - 1050年）考古发掘出的两例骨骼发育异常病例进行研究。
在此检查了两具保存状况尚可的骨骼遗骸，一具为成年人，一具为青少年。
对所有可用的骨骼元素进行宏观分析。对每个个体进行鉴别诊断。
成年个体U36.Sh2.B10表现为双侧中肢发育异常和马德隆畸形。青少年个体U36.Sh2.B5也表现为双侧中肢发育异常以及与马德隆畸形相关的特征。
建议对成年女性个体（U36.Sh2.B10）进行勒里 - 韦伊软骨发育不全（LWD）的鉴别诊断。第二例（U36.Sh2.B5）是一名约3至5岁的个体，鉴于其年龄较小，难以诊断；然而，LWD仍是最可能的诊断。
在古病理学文献中，LWD病例较少，青少年病例更少。所描述的病例是扩展研究的有用实例，证明了青少年和成年人骨骼发育异常表现的变异性。
颅骨和部分颅后骨骼的埋藏学改变和破碎限制了对与骨骼发育异常相关的全套特征的观察。鉴于U36.Sh2.B5个体年龄较小且可能尚未发育出与这些病症相关的更易观察到的特征，所以难以诊断。
鼓励研究人员继续研究青少年和成年人骨骼发育异常的表现范围。
