Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China.
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
J Nanobiotechnology. 2021 Jun 28;19(1):192. doi: 10.1186/s12951-021-00936-y.
It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.
由于癌症死亡率的不断上升，实现有效和安全的抗癌治疗已刻不容缓。需要设计新型抗癌药物和策略以提高治疗效果。基于 Fenton 和类 Fenton 反应的化学动力学治疗（CDT）是增强抗癌疗效的新策略，因为它能够产生活性氧（ROS）和氧气（O）。一方面，生成的 ROS 可以直接损伤癌细胞。另一方面，生成的 O 可以缓解肿瘤微环境（TME）中的缺氧状态，这会阻碍光动力疗法、放射疗法等的有效实施。因此，CDT 可以与许多其他治疗策略联合使用，以协同增强联合治疗效果。本文将讨论基于 Fenton 和类 Fenton 反应的纳米材料在抗肿瘤方面的应用，包括：（i）原位产生丰富的 ROS 直接杀伤癌细胞，（ii）通过 Fenton 反应介导的联合治疗间接增强治疗效果，（iii）癌症治疗的诊断和监测。这些策略展示了基于 CDT 的纳米材料在高效癌症治疗方面的潜力。
