The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
University of the Chinese Academy of Sciences, Beijing, China.
Nat Prod Res. 2021 Apr;35(8):1388-1392. doi: 10.1080/14786419.2019.1647429. Epub 2019 Aug 5.
Seventeen phenolic glycosides were isolated from the Their structures were identified by the spectroscopic data and comparison with literatures as isovanillyl alcohol-7----glucopyranoside (), benzyl -primeveroside (), benzyl----glucopyranoside (), 1----glucopyranosyl-4-(8-hydroxyethyl)-2-methoxyphenyl (), dehydrosyringin (), trans-ferulic acid-4----glucoside (), -ferulic acid 4----glucopyranoside (), glucosyringic acid (), 1--feruloyl---glucoside (), sachaloside VII (), (3, 5, 6, 7, 9)-megastigmane-7-ene-3-hydroxy-5,6-epoxy-9----glucopyranoside(), 3-hydroxy-4,5-dimethoxybenzyl alcohol (), pinoresinol 4----glucopyranoside (), eucommin A (), isoeucommin A (), acanthoside (), liriodendrin (). All these compounds except compound were isolated from the genus for the first time. In bioactivity assays for all compounds, the compounds and were exhibited strong antioxidant activity (IC = 18.11 and 16.29 μM respectively), while compounds and were exhibited strong PTP1B enzymatic inhibition (IC = 6.97 and 11.76 μM, respectively). Furthermore, the compounds and were presented strong inhibitory capacities against (14.5 and 13.5 mm, respectively).
从该植物中分离得到 17 个酚糖苷。通过光谱数据和与文献的比较，鉴定了它们的结构，分别为异香草醇-7----葡萄糖苷()、苯甲基首马钱苷()、苯甲基----葡萄糖苷()、1----葡萄糖基-4-(8-羟乙基)-2-甲氧基苯基()、脱水丁香素()、反式阿魏酸-4----葡萄糖苷()、对香豆酸 4----葡萄糖苷()、葡萄糖丁香酸()、1--阿魏酰---葡萄糖苷()、沙蟾毒精 VII()、(3,5,6,7,9)-megastigmane-7-ene-3-hydroxy-5,6-epoxy-9----葡萄糖苷()、3-羟基-4,5-二甲氧基苄醇()、松脂醇 4----葡萄糖苷()、广寄生素 A()、异广寄生素 A()、菖蒲苷()、莲心碱()。除化合物 外，所有这些化合物均为首次从该属植物中分离得到。在所有化合物的生物活性测定中，化合物 和 表现出很强的抗氧化活性（IC = 18.11 和 16.29 μM 分别），而化合物 和 表现出很强的 PTP1B 酶抑制活性（IC = 6.97 和 11.76 μM，分别）。此外，化合物 和 对 （14.5 和 13.5 mm，分别）表现出很强的抑制能力。
