Department of Clinical Biochemistry and Pharmacology, Tomas Bata Hospital, Zlín, Czech Republic.
Department of Biomedical Sciences, Medical Faculty of the University of Ostrava, Ostrava - Zábřeh, Czech Republic.
Biochem Med (Zagreb). 2019 Oct 15;29(3):030704. doi: 10.11613/BM.2019.030704. Epub 2019 Aug 5.
The aim of the study is to assess the degree of adherence of medical laboratories to Kidney Disease Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD) in laboratory practice in Czechia and Slovakia.
An electronic questionnaire on adherence to KDIGO 2012 guideline was designed by an external quality assessment (EQA) provider SEKK spol. s.r.o. The questionnaire was placed and distributed through website to all medical biochemistry laboratories in Czechia and Slovakia (N = 396).
A total of 212 out of 396 laboratories responded to the questions, though some laboratories only answered some questions, those applicable to their practice. A total of 48 out of 212 laboratories adopted the KDIGO 2012 guideline in full extent. The metrological traceability of creatinine measurement to standard reference material of SRM 967 was declared by 180 out of 210 laboratories (two of the responding laboratories did not measure creatinine). Thirty laboratories are not well educated on traceability of creatinine measurement and seven laboratories do not calculate estimated glomerular filtration rate (eGFR). Both urinary albumin concentration and albumin to creatinine ratio are reported by 144 out of 175 laboratories (37 of the responding laboratories did not measure urinary albumin).
Majority of laboratories in Czechia and Slovakia adopted some parts of the KDIGO 2012 guideline in their practice, but only 23% of the laboratories apply them completely. Thus, further education and action should be conducted to improve its implementation.
本研究旨在评估捷克共和国和斯洛伐克的医学实验室在实验室实践中遵循肾脏病改善全球结局组织(KDIGO)2012 年慢性肾脏病(CKD)评估和管理临床实践指南的程度。
由外部质量评估(EQA)提供商 SEKK spol. s.r.o. 设计了一份关于遵循 KDIGO 2012 指南的电子问卷。问卷通过网站分发给捷克共和国和斯洛伐克的所有医学生化实验室(N=396)。
尽管有些实验室只回答了适用于其实践的部分问题,但在 396 个实验室中有 212 个实验室对这些问题做出了回应。共有 48 个实验室完全采用了 KDIGO 2012 指南。210 个实验室中有 180 个实验室声明肌酐测量的计量溯源性符合标准参考物质 SRM 967(两个回应实验室未测量肌酐)。30 个实验室对肌酐测量的溯源性教育不足,7 个实验室不计算估计肾小球滤过率(eGFR)。在 175 个实验室中有 144 个实验室报告了尿白蛋白浓度和白蛋白/肌酐比值(37 个回应实验室未测量尿白蛋白)。
捷克共和国和斯洛伐克的大多数实验室在其实践中采用了 KDIGO 2012 指南的某些部分,但只有 23%的实验室完全应用它们。因此,应进一步开展教育和行动,以改善其实施。