Lemmens H J, Burm A G, Bovill J G, Hennis P J
Department of Anaesthesiology, University Hospital, Leiden, The Netherlands.
Br J Anaesth. 1988 Aug;61(2):173-9. doi: 10.1093/bja/61.2.173.
The pharmacodynamics of alfentanil given as a supplement to nitrous oxide anaesthesia were studied in 10 elderly patients undergoing lower abdominal surgery. Plasma alfentanil concentration-effect curves for perioperative stimuli and for the probability of needing naloxone at the end of surgery were fitted by logistic regression. The concentration at which the probability of no response was 0.5 (Cp50) for laryngoscopy was 356 ng ml-1, for opening the peritoneum 295 ng ml-1 and for closing the peritoneum 254 ng ml-1. The average Cp50 for the intra-abdominal part of the operation was 268 +/- 97 ng ml-1. The Cp50 for needing naloxone was 174 ng ml-1. These findings are similar to published values for young healthy females undergoing lower abdominal surgery. Our findings suggest that the pharmacodynamics of alfentanil in the elderly are similar to those in younger adults.
对10例接受下腹部手术的老年患者，研究了在氧化亚氮麻醉中追加阿芬太尼的药效学。通过逻辑回归拟合围手术期刺激的血浆阿芬太尼浓度-效应曲线以及手术结束时需要纳洛酮的概率。喉镜检查无反应概率为0.5（Cp50）时的浓度，喉镜检查为356 ng/ml，打开腹膜为295 ng/ml，关闭腹膜为254 ng/ml。手术腹腔内部分的平均Cp50为268±97 ng/ml。需要纳洛酮的Cp50为174 ng/ml。这些结果与已发表的接受下腹部手术的年轻健康女性的值相似。我们的研究结果表明，阿芬太尼在老年人中的药效学与年轻人相似。
