心脏瓣膜的个性化建模：从图像到模拟
Patient-Specific Modeling of Heart Valves: From Image to Simulation.
作者信息
Aggarwal Ankush, Aguilar Vanessa S, Lee Chung-Hao, Ferrari Giovanni, Gorman Joseph H, Gorman Robert C, Sacks Michael S
机构信息
Institute of Computational Engineering & Sciences, University of Texas at Austin Austin, TX 78712.
Department of Biomedical Engineering, University of Texas at Austin Austin, TX 78712.
出版信息
Funct Imaging Model Heart. 2013 Jun;7945:141-149. doi: 10.1007/978-3-642-38899-6_17.
Abstract
Heart valves play a very important role in the functioning of the heart and many of the heart failures are related to the valvular dysfunctions, e.g. aortic stenosis and mitral regurgitation. As the medical field is moving towards a patient-specific diagnosis and treatment procedures, modeling of heart valves with patient-specific information is becoming a significant tool in medical field. Here we present the ingredients for valve simulation specifically the aortic valve, with a main focus on a novel spline-based mapping technique which solves many issues in generating patient-specific models - the microstructural mapping, the pre-strain calculations, prescribing dynamic boundary conditions, validation and inverse-modeling to obtain material parameters.
摘要
心脏瓣膜在心脏功能中起着非常重要的作用，许多心力衰竭都与瓣膜功能障碍有关，例如主动脉瓣狭窄和二尖瓣反流。随着医学领域朝着针对患者的诊断和治疗程序发展，利用患者特定信息对心脏瓣膜进行建模正成为医学领域的一项重要工具。在此，我们介绍瓣膜模拟的要素，特别是主动脉瓣，主要关注一种基于样条的新型映射技术，该技术解决了生成患者特定模型中的许多问题——微观结构映射、预应变计算、规定动态边界条件、验证以及用于获取材料参数的逆建模。
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