Al-Khateeb Mashael, Adem Fatima, Moqbel Amani, Baz Salah
Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia. E-mail:
Neurosciences (Riyadh). 2019 Jul;24(3):240-244. doi: 10.17712/nsj.2018.3.20180014.
New-onset refractory status epilepticus (NORSE) is a drug-resistant status epilepticus that often has a catastrophic outcome. Our patient was diagnosed with NORSE and had an EEG reading that showed status epilepticus persisting for 8 months in general anesthesia. After autoimmune workup showed positive antiphospholipid antibodies, his seizure was controlled, and he was discharged with good condition apart from moderate cognitive impairment. However, he later developed schizophrenia. Although psychiatric disorders have been associated with antiphospholipid syndrome, to the best of our knowledge, it has not been reported to be associated with status epilepticus. We recommend vigilance of psychological complications of refractory status epilepticus patients for early psychiatric referral, diagnosis, and treatment.
新发难治性癫痫持续状态（NORSE）是一种耐药性癫痫持续状态，通常会导致灾难性后果。我们的患者被诊断为NORSE，脑电图显示癫痫持续状态在全身麻醉下持续了8个月。自身免疫检查显示抗磷脂抗体呈阳性后，他的癫痫发作得到控制，除中度认知障碍外，出院时情况良好。然而，他后来患上了精神分裂症。虽然精神障碍与抗磷脂综合征有关，但据我们所知，尚未报道其与癫痫持续状态有关。我们建议对难治性癫痫持续状态患者的心理并发症保持警惕，以便早期进行精神科转诊、诊断和治疗。
