Centre for Academic Child Health, University of Bristol, 1-5 Whiteladies Road, Bristol, BS8 1NU, UK.
School of Sport, Exercise and Health Sciences, Loughborough University, Epinal Way, Loughborough, LE11 3TU, UK.
J Adolesc. 2019 Aug;75:123-129. doi: 10.1016/j.adolescence.2019.07.014. Epub 2019 Aug 2.
We investigated whether depressive symptoms at ages 9-13 years were associated with chronic disabling fatigue (CDF) at age 16 among children in the Avon Longitudinal Study of Parents & Children (ALSPAC) birth cohort.
Depressive symptoms at ages 9, 10, 11, 12, and 13 years were defined as a child- or parent-completed Short Mood and Feelings Questionnaire (SMFQ) score ≥11 (range 0-26). SMFQ score was also analysed as a continuous exposure. Chronic disabling fatigue at 16 was defined as fatigue of ≥6 months' but <5 years' duration which prevented school attendance or activities, for which other causes were not identified, and with a Chalder Fatigue Questionnaire score ≥19. Logistic regression was used with multiple imputation to correct for missing data bias. We performed sensitivity analyses in which children who had CDF and depressive symptoms at age 16 were reclassified as not having CDF.
In fully adjusted models using imputed data (N = 13,978), depressive symptoms at ages 9, 11, and 13 years were associated with 2- to 3-fold higher odds of CDF at age 16. Each one-point increase in SMFQ score at ages 9, 10, 11, 12, and 13 years was associated with 6-11% higher odds of CDF at age 16. Depressive symptoms and continuous SMFQ scores at each age were not associated with CDF if the outcome was reclassified to exclude children with comorbid depressive symptoms at age 16.
Depressive symptoms at ages 9-13 were associated with chronic disabling fatigue at age 16, but causality is not certain.
我们研究了在阿冯纵向父母与子女研究（ALSPAC）出生队列中，9-13 岁时的抑郁症状是否与 16 岁时的慢性致残性疲劳（CDF）有关。
9、10、11、12 和 13 岁时的抑郁症状定义为儿童或家长完成的短情绪和感觉问卷（SMFQ）评分≥11（范围 0-26）。SMFQ 评分也作为连续暴露进行分析。16 岁时的慢性致残性疲劳定义为≥6 个月但<5 年的疲劳，这种疲劳会妨碍上学或活动，没有发现其他原因，并且 Chalder 疲劳问卷评分≥19。使用逻辑回归和多重插补来纠正缺失数据偏差。我们进行了敏感性分析，将 16 岁时患有 CDF 和抑郁症状的儿童重新分类为没有 CDF。
在使用插补数据的完全调整模型中（N=13978），9、11 和 13 岁时的抑郁症状与 CDF 在 16 岁时的两倍至三倍的更高的几率相关。9、10、11、12 和 13 岁时的 SMFQ 评分每增加一分，与 16 岁时 CDF 的几率增加 6-11%相关。如果将结局重新分类以排除 16 岁时患有共病抑郁症状的儿童，则每个年龄时的抑郁症状和连续 SMFQ 评分与 CDF 无关。
9-13 岁时的抑郁症状与 16 岁时的慢性致残性疲劳有关，但因果关系尚不确定。
