Riedel Stefan
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Yamins 309, Boston, MA 02215, USA.
Clin Lab Med. 2019 Sep;39(3):453-472. doi: 10.1016/j.cll.2019.05.011.
Sepsis and pneumonia cause significant morbidity and mortality worldwide. Despite improvements in diagnostic methodologies for organism identification, the early recognition and further risk stratification of these infections can be challenging. Although traditional clinical scoring systems are beneficial for the management of sepsis and pneumonia, biomarkers supporting the diagnosis and management of these infectious diseases are needed. Many biomarkers have been identified and there is no lack of studies and meta-analyses assessing the utility of biomarkers. Focusing primarily on sepsis and pneumonia, this article discusses the most commonly used biomarkers for which clinical laboratory testing methods are available.
脓毒症和肺炎在全球范围内导致了显著的发病率和死亡率。尽管在病原体鉴定的诊断方法方面有所改进，但对这些感染的早期识别和进一步的风险分层仍具有挑战性。虽然传统的临床评分系统有助于脓毒症和肺炎的管理，但仍需要支持这些传染病诊断和管理的生物标志物。已经鉴定出许多生物标志物，并且不乏评估生物标志物效用的研究和荟萃分析。本文主要聚焦于脓毒症和肺炎，讨论了有临床实验室检测方法可用的最常用生物标志物。
