École Nationale des Services Vétérinaires, VetAgro Sup, 69280 Marcy l'Étoile, France; Université de Lyon, ANSES, Laboratoire de Lyon, Unité Épidémiologie et appui à la surveillance, 31 avenue Tony Garnier, 69007 Lyon, France; EPIA, UMR Epidémiologie des Maladies Animales et Zoonotiques, INRA, VetAgro Sup, Université de Lyon, 69280, Marcy L'Etoile, France.
Université de Lyon, ANSES, Laboratoire de Lyon, Unité Épidémiologie et appui à la surveillance, 31 avenue Tony Garnier, 69007 Lyon, France.
Vet Microbiol. 2019 Aug;235:280-284. doi: 10.1016/j.vetmic.2019.07.017. Epub 2019 Jul 21.
Surveillance of Pasteurella multocida resistance in food-producing animals is essential to guide the first-line treatment of respiratory diseases and to limit economic losses. Since Pasteurella are the most common bacteria isolated from dog and cat bites, this surveillance is also needed to guide treatment in humans in case of bites. The aim of this study was to characterize the phenotypic resistance of P. multocida strains isolated from respiratory infections in animals, including both food-producing animals and pets. Data collected between 2012 and 2017 by the French national surveillance network for antimicrobial resistance referred to as RESAPATH were analyzed. The proportions of resistance to antimicrobials of relevance in veterinary and human medicines were estimated for each animal species. For cattle, resistance trends over the period were investigated using non-linear analysis applied to time-series. In total, 5356 P. multocida isolates were analyzed. Proportions of resistance of P. multocida were almost all below 20% over the period, and, more precisely, all resistance proportions were below 10% for rabbits, sheep and dogs. The highest resistance proportions to enrofloxacin were identified for cattle (4.5%) and dogs (5.2%). Despite its frequent use in livestock, resistance to florfenicol was less than 1% in P. multocida strains, regardless of the animal species considered. Time series analyses revealed continuous increases in resistance to tetracycline, tilmicosin, flumequine and fluoroquinolones in P. multocida strains isolated from cattle. These trends contrast with the decrease in use of antibiotics in cattle in France and with the decrease in resistance observed in E. coli isolated from diseased cattle.
监测生产动物中多杀巴斯德氏菌的耐药性对于指导呼吸道疾病的一线治疗和限制经济损失至关重要。由于巴斯德氏菌是从狗和猫咬伤中分离出来的最常见的细菌，因此在发生咬伤时，还需要对人进行这种监测，以指导治疗。本研究的目的是描述从动物呼吸道感染中分离出的多杀巴斯德氏菌菌株的表型耐药性，包括生产动物和宠物。分析了 2012 年至 2017 年期间法国国家抗菌药物耐药性监测网络 RESAPATH 收集的数据。估计了每种动物物种中兽医和人类医学中相关抗菌药物的耐药比例。对于牛，使用时间序列分析中的非线性分析研究了该期间的耐药趋势。共分析了 5356 株多杀巴斯德氏菌。在整个研究期间，多杀巴斯德氏菌的耐药比例几乎都低于 20%，更确切地说，兔子、绵羊和狗的所有耐药比例都低于 10%。对恩诺沙星的耐药比例最高的是牛（4.5%）和狗（5.2%）。尽管氟苯尼考在畜牧业中经常使用，但多杀巴斯德氏菌对其的耐药性低于 1%，无论所考虑的动物物种如何。时间序列分析显示，从牛中分离出的多杀巴斯德氏菌对四环素、替米考星、氟苯尼考和氟喹诺酮类药物的耐药性持续增加。这些趋势与法国牛中抗生素使用量的减少以及从患病牛中分离出的大肠杆菌耐药性的下降形成对比。
