Siteavu Madalina Iulia, Drugea Roxana Ionela, Pitoiu Elena, Ciobotaru-Pirvu Emilia
Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 050097 Bucharest, Romania.
Synevovet Laboratory, Ilfov County, 077040 Chiajna, Romania.
Microorganisms. 2023 Sep 27;11(10):2410. doi: 10.3390/microorganisms11102410.
Antimicrobial resistance is an important health issue in human and veterinary medicine. The aim of this study was to monitor the antimicrobial resistance of three of the most important bacteria involved in porcine respiratory disease. A total of 465 isolates were tested during the 2017-2022 period for antimicrobial susceptibility for (n = 137), (n = 207), and (n = 121) by disk diffusion method. The results were interpreted by CLSI breakpoints, where available. High rates of susceptibility (from 90 to >99%) were observed for cefquinome, ceftiofur, amoxicillin + clavulanic acid, amoxicillin, penicillin, ampicillin, florfenicol, enrofloxacin, marbofloxacin, and trimethoprim-sulfamethoxazole. isolates showed high resistance to streptomycin (77%), gentamycin (45%), tilmicosin (39%) erythromycin (33%), oxytetracycline (19%), and tetracycline (18%). For , the highest rates of resistance were observed for streptomycin (98%), tetracycline (75%), oxytetracycline (72%), doxycycline (52%), and erythromycin (51%). presented a high rate of resistance for streptomycin (63%), tilmicosin (29%), oxytetracycline (13%), and tetracycline (14%). Bacteria isolates maintained high susceptibility against antimicrobial agents usually used against the mainly respiratory tract pathogens of swine. Resistance for streptomycin, tetracycline, oxytetracycline, and tilmicosin was high for all the tested pathogens.
抗菌药物耐药性是人类医学和兽医学中的一个重要健康问题。本研究的目的是监测猪呼吸道疾病中三种最重要细菌的抗菌药物耐药性。在2017年至2022年期间，通过纸片扩散法对总共465株分离株进行了针对猪肺炎支原体（n = 137）、猪肺炎放线杆菌（n = 207）和多杀性巴氏杆菌（n = 121）的抗菌药物敏感性测试。结果在可行的情况下根据美国临床和实验室标准协会（CLSI）的断点进行解释。对于头孢喹肟、头孢噻呋、阿莫西林+克拉维酸、阿莫西林、青霉素、氨苄西林、氟苯尼考、恩诺沙星、马波沙星和甲氧苄啶-磺胺甲恶唑，观察到高敏感性率（从90%到>99%）。猪肺炎支原体分离株对链霉素（77%）、庆大霉素（45%）、替米考星（39%）、红霉素（33%）、土霉素（19%）和四环素（18%）表现出高耐药性。对于猪肺炎放线杆菌，链霉素（98%）、四环素（75%）、土霉素（72%）、强力霉素（52%）和红霉素（51%）的耐药率最高。多杀性巴氏杆菌对链霉素（63%）、替米考星（29%）、土霉素（13%）和四环素（14%）表现出高耐药率。细菌分离株对通常用于对抗猪主要呼吸道病原体的抗菌药物保持高敏感性。所有测试病原体对链霉素、四环素、土霉素和替米考星的耐药性都很高。
