与喹硫平相关的逆行射精及低剂量丙咪嗪治疗
Retrograde ejaculation associated with quetiapine and treatment with low-dose imipramine.
作者信息
Roughley Matthew, Lyall Marc
机构信息
City and Hackney Centre for Mental Health, East London NHS Foundation Trust, London, UK.
John Howard Centre, East London NHS Foundation Trust, London, UK.
出版信息
BMJ Case Rep. 2019 Aug 4;12(8):e228539. doi: 10.1136/bcr-2018-228539.
Sexual side-effects are common among those using antipsychotic medication and may result in poor compliance and reduced quality of life. Retrograde ejaculation (RE) has been described occurring with a number of antipsychotic medications (thioridazine, risperidone, iloperidone and clozapine) but there are no guidelines regarding management of antipsychotic-associated RE. Imipramine has been suggested as a treatment for antipsychotic-associated RE in one small study of patients prescribed thioridazine and a case series of patients prescribed iloperidone. Quetiapine is a commonly used antipsychotic and is thought to be associated with less sexual side-effects relative to other antipsychotic medications. This case report describes a 25-year-old man with first episode psychosis who developed RE during treatment with quetiapine which improved with low-dose imipramine. This is the first description of RE occurring with quetiapine and successful treatment of quetiapine-associated RE with imipramine.
性功能副作用在服用抗精神病药物的人群中很常见，可能导致服药依从性差和生活质量下降。已有报道称，多种抗精神病药物（硫利达嗪、利培酮、伊潘立酮和氯氮平）会导致逆行射精（RE），但对于抗精神病药物相关逆行射精的管理尚无指南。在一项针对服用硫利达嗪的患者的小型研究以及一系列服用伊潘立酮的患者病例中，有人提出丙咪嗪可用于治疗抗精神病药物相关的逆行射精。喹硫平是一种常用的抗精神病药物，与其他抗精神病药物相比，它被认为引起的性功能副作用较少。本病例报告描述了一名25岁的首次发作精神病男性患者，在服用喹硫平治疗期间出现逆行射精，低剂量丙咪嗪治疗后病情改善。这是关于喹硫平导致逆行射精以及丙咪嗪成功治疗喹硫平相关逆行射精的首次报道。
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