Tékpa Gaspard, Fikouma Valentin, Téngothi Régis Martial Marada, Longo Jean de Dieu, Woyengba Avilah Phrygie Amakadé, Koffi Boniface
Service des Maladies Infectieuses, Hôpital de l'Amitié, Bangui, République Centrafricaine.
Centre de Traitement Ambulatoire de l'Infection à VIH, Hôpital Communautaire, Bangui, République Centrafricaine.
Pan Afr Med J. 2019 May 15;33:31. doi: 10.11604/pamj.2019.33.31.13442. eCollection 2019.
Tuberculosis (TB) is endemic in the Central African Republic (CAR) with an incidence rate of 391 per 100,000 population in 2015. This study aims to analyze current epidemiological and clinical features of TB at the Hôpital de l'Amitié in the Central African Republic. We conducted an analytic retrospective study of patients hospitalized in the Department of Medicine at the Hôpital de l'Amitié from 15 April 2010 to 14 October 2011. Data were collected using a questionnaire and then analyzed with Epi info software 3.5.3. Chi-square test was used to compare proportions, using a threshold significance level of 5%. The study included 220 patients, of whom 128 were women (58.18%). The average age of patients was 35.69± 10.65 years. In 42.70% of cases, patients had no professional activity. Prevalence of tuberculosis in hospital was 10.99%. On average, 12 cases of TB were recorded each month. Most common clinical signs included: chronic cough (71.81%), fever (96.82%), alteration of the general state (91.36%) and pulmonary condensation syndrome (63.64%). The diseases most commonly associated with tuberculosis were HIV/AIDS (73.36%), malaria (48.63%) and anemia (31.81%). The mean time between symptom onset and diagnosis was 37.65 days. Mortality rate was 18.63%. TB/HIV co-infection and neuromeningeal TB were associated with a high mortality rate (p < 0.05). Tuberculosis is a common disease in Bangui and it is often associated with HIV infection. Prognosis is poor in the case of neuromeningeal involvement. Prevention and routine monitoring in HIV infected patients may contribute to reduce the extent and severity of TB.
结核病（TB）在中非共和国（CAR）呈地方性流行，2015年发病率为每10万人口391例。本研究旨在分析中非共和国友谊医院结核病的当前流行病学和临床特征。我们对2010年4月15日至2011年10月14日在友谊医院内科住院的患者进行了一项分析性回顾性研究。使用问卷收集数据，然后用Epi info软件3.5.3进行分析。采用卡方检验比较比例，显著性水平阈值为5%。该研究纳入了220例患者，其中128例为女性（58.18%）。患者的平均年龄为35.69±10.65岁。在42.70%的病例中，患者没有职业活动。医院内结核病患病率为10.99%。平均每月记录12例结核病病例。最常见的临床症状包括：慢性咳嗽（71.81%）、发热（96.82%）、全身状况改变（91.36%）和肺部实变综合征（63.64%）。与结核病最常相关的疾病是艾滋病毒/艾滋病（73.36%）、疟疾（48.63%）和贫血（31.81%）。症状出现到诊断的平均时间为37.65天。死亡率为18.63%。结核病/艾滋病毒合并感染和结核性脑膜炎与高死亡率相关（p<0.05）。结核病在班吉是一种常见疾病，且常与艾滋病毒感染相关。结核性脑膜炎累及的情况下预后较差。对艾滋病毒感染患者进行预防和常规监测可能有助于降低结核病的范围和严重程度。
