Werner de Castro Glaucio R, Buss Ziliani Da Silva, Rosa Julia Salvan, Facchin Bruno M, Fröde Tania S
Rheumatology, University of Southern Santa Catarina, Florianopolis, BRA.
Clinical Analysis, Federal University of Santa Catarina, Florianopolis, BRA.
Cureus. 2019 May 31;11(5):e4791. doi: 10.7759/cureus.4791.
To evaluate serum levels of bone metabolism biomarkers in patients with Paget's disease of bone (PDB).
Serum levels of osteopontin, sclerostin, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin, Dickkopf-related protein 1 (DKK-1), and soluble frizzled-related protein 1 (sFRP-1) were measured in 57 patients with Paget's disease of bone and 24 controls with primary osteoarthritis. Subgroup analysis was employed to identify any differences in bone metabolism biomarker levels according to disease activity or current treatment.
Patients with PDB presented higher levels of osteopontin and RANKL. When compared with patients with inactive disease, patients with active disease presented higher levels of bone-specific alkaline phosphatase (BAP) and osteopontin. There was a significant correlation between serum levels of BAP and osteopontin. There was no significant correlation between levels of BAP and other bone metabolism biomarkers. Current disease extension on bone scintigraphy had a significant correlation with serum levels of osteopontin and BAP. There was no significant correlation between current disease extension and other bone metabolism biomarkers. Serum levels of osteopontin and RANKL were correlated to serum levels of BAP and disease extension.
Patients with PDB presented higher levels of osteopontin and RANKL. Osteopontin could be a useful biomarker for activity and extension of PDB.
评估骨Paget病（PDB）患者骨代谢生物标志物的血清水平。
测定了57例骨Paget病患者和24例原发性骨关节炎对照者血清中骨桥蛋白、硬化蛋白、核因子κB受体活化因子配体（RANKL）、骨保护素、Dickkopf相关蛋白1（DKK-1）和可溶性卷曲相关蛋白1（sFRP-1）的水平。采用亚组分析根据疾病活动度或当前治疗来确定骨代谢生物标志物水平的差异。
PDB患者骨桥蛋白和RANKL水平较高。与疾病不活动的患者相比，疾病活动的患者骨特异性碱性磷酸酶（BAP）和骨桥蛋白水平较高。BAP和骨桥蛋白的血清水平之间存在显著相关性。BAP水平与其他骨代谢生物标志物之间无显著相关性。骨闪烁显像上当前的疾病范围与骨桥蛋白和BAP的血清水平显著相关。当前疾病范围与其他骨代谢生物标志物之间无显著相关性。骨桥蛋白和RANKL的血清水平与BAP的血清水平和疾病范围相关。
PDB患者骨桥蛋白和RANKL水平较高。骨桥蛋白可能是PDB活动度和范围的有用生物标志物。
