Department of Veterinary Anatomy, College of Veterinary Medicine, Jeju National University, Republic of Korea.
Acta Histochem. 2012 Dec;114(8):749-54. doi: 10.1016/j.acthis.2012.08.004. Epub 2012 Sep 1.
Osteopontin (OPN) plays an important role in the initiation of inflammation, affecting cell adhesion, chemotaxis, immune regulation, and protection against apoptosis, depending on its intracellular or extracellular localization. Although OPN in inflammation of the autoimmune central nervous system is proinflammatory, recent studies have shown that OPN during the induction stage of inflammation may also participate in neuroprotection and neurite growth. The present review examines the dual roles of OPN, specifically, its proinflammatory and subsequent neuroprotective roles, in acute neuroinflammation in rat models, including experimental autoimmune encephalomyelitis, brain injury, and autoimmune neuritis. All of these models are characterized by acute neuroinflammation, followed by remodeling of neural tissues.
骨桥蛋白（OPN）在炎症的启动中起着重要作用，其根据细胞内或细胞外的定位，影响细胞黏附、趋化、免疫调节和抗细胞凋亡作用。尽管自身免疫性中枢神经系统炎症中的 OPN 具有促炎作用，但最近的研究表明，炎症诱导阶段的 OPN 也可能参与神经保护和神经突生长。本综述检查了 OPN 的双重作用，即在实验性自身免疫性脑脊髓炎、脑损伤和自身免疫性神经炎等大鼠模型的急性神经炎症中，其具体表现为促炎作用和随后的神经保护作用。所有这些模型的特点都是急性神经炎症，随后是神经组织的重塑。
