调节急性髓细胞白血病中的生物学反应。II. 卡介苗和白血病细胞对淋巴细胞对有丝分裂原的反应以及辅助和抑制活性的影响。
Modifying the biological response in acute myeloid leukemia. II. Effect of BCG and leukemic cells on lymphocyte response to mitogens, and on helper and suppressor activity.
作者信息
Arends-Merino A, Giscombe R, Ogier C, Reizenstein P, Sjörgen A M, Wasserman J
出版信息
Cancer Immunol Immunother. 1982;14(1):32-5. doi: 10.1007/BF00199429.
Lymphocyte response to mitogens and to lymphocyte suppressor and monocyte helper activity was studied in 18 patients with acute myeloid leukemia in complete remission, and in 17 healthy controls. Ten patients were maintained with chemotherapy alone (CT), and eight received chemoimmunotherapy with BCG + leukemic cells (CIT). In late remission the mitogen responsiveness was increased in CT patients and decreased in CIT patients. No significant difference in lymphocyte suppressor activity could be demonstrated between patients and controls, or between CT and CIT. When autologous CIT monocytes were added to mitogen-stimulated lymphocytes they acted as helper cells. CT monocytes, in contrast, seemed to act as suppressor cells. Control monocytes also acted as helper cells, but to a significantly lesser degree than CIT monocytes.
对18例急性髓系白血病完全缓解患者和17名健康对照者的淋巴细胞对丝裂原、淋巴细胞抑制活性及单核细胞辅助活性的反应进行了研究。10例患者仅接受化疗（CT）维持治疗，8例接受卡介苗+白血病细胞的化学免疫治疗（CIT）。在缓解后期，CT组患者的丝裂原反应性增加，CIT组患者的丝裂原反应性降低。患者与对照者之间，或CT组与CIT组之间，淋巴细胞抑制活性均无显著差异。当将自体CIT单核细胞加入丝裂原刺激的淋巴细胞时，它们起到辅助细胞的作用。相比之下，CT单核细胞似乎起到抑制细胞的作用。对照单核细胞也起到辅助细胞的作用，但程度明显低于CIT单核细胞。
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