伴刀豆球蛋白A激活的人淋巴细胞对DNA合成的抑制作用：单核细胞在伴刀豆球蛋白A诱导的抑制作用中的作用。
Suppression of DNA synthesis by con A-activated human lymphocytes: role of monocytes in con A-induced suppression.
作者信息
Kallenberg C G, de Gast G C, The T H
出版信息
Clin Exp Immunol. 1980 Sep;41(3):583-90.
Human peripheral blood mononuclear leucocytes, activated by Con A, suppress the antigen- or mitogen-induced proliferation of autologous responder cells. Generation of suppressor cells is prevented by mitomycin treatment before Con A activation. Once cells are activated, their suppressive activity is not affected by mitomycin treatment. Monocytes are not only required for generation of suppressor cells, but are also involved in suppression as effector cells. Monocyte-mediated suppression is blocked by indomethacin, suggesting that this suppression is mediated by prostaglandin. It is concluded that monocytes are involved in Con A-induced suppression of DNA synthesis.
经刀豆蛋白A激活的人外周血单核白细胞可抑制自体反应细胞的抗原或丝裂原诱导的增殖。在刀豆蛋白A激活前用丝裂霉素处理可阻止抑制细胞的产生。一旦细胞被激活，其抑制活性不受丝裂霉素处理的影响。单核细胞不仅是产生抑制细胞所必需的，而且作为效应细胞也参与抑制作用。吲哚美辛可阻断单核细胞介导的抑制作用，提示这种抑制作用是由前列腺素介导的。结论是单核细胞参与刀豆蛋白A诱导的DNA合成抑制。
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