lncRNA Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis.

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) could participate in diverse cancers. Among these, lymphoid enhancer-binding factor 1 antisense RNA 1 () was recently identified as an oncogenic lncRNA, but little is known about its function in non-small-cell lung cancer (NSCLC). In the present study, we found that was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration and . could bind with and further negatively regulate - to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that promoted NSCLC tumorigenesis dependent on the -SOX4 axis and implicated the potential application of for the prognosis and treatment of NSCLC.