Seo Danbi, Kim Dain, Chae Yeonsoo, Kim Wanyeon
Department of Science Education, Korea National University of Education, Cheongju 28173, Korea.
Department of Science Education, Chungbuk Science High School, Cheongju 28189, Korea.
Genomics Inform. 2020 Dec;18(4):e36. doi: 10.5808/GI.2020.18.4.e36. Epub 2020 Dec 21.
Since lung cancer is a major causative for cancer-related deaths, the investigations for discovering biomarkers to diagnose at an early stage and to apply therapeutic strategies have been continuously conducted. Recently, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are being exponentially studied as promising biomarkers of lung cancer. Moreover, supportive evidence provides the competing endogenous RNA (ceRNA) network between lncRNAs and miRNAs participating in lung tumorigenesis. This review introduced the oncogenic or tumor-suppressive roles of lncRNAs and miRNAs in lung cancer cells and summarized the involvement of the lncRNA/miRNA ceRNA networks in carcinogenesis and therapeutic resistance of lung cancer.
由于肺癌是癌症相关死亡的主要原因，人们一直在持续开展研究以发现用于早期诊断和应用治疗策略的生物标志物。最近，长链非编码RNA（lncRNA）和微小RNA（miRNA）作为有前景的肺癌生物标志物正受到大量研究。此外，有支持性证据表明lncRNA和miRNA之间存在参与肺肿瘤发生的竞争性内源性RNA（ceRNA）网络。本综述介绍了lncRNA和miRNA在肺癌细胞中的致癌或抑癌作用，并总结了lncRNA/miRNA ceRNA网络在肺癌发生和治疗耐药性中的作用。
