Department of Burnsand Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, PR China.
Department of Orthopedic Surgery, Xiangyang Central Hospital, The Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, PR China.
Biomed Pharmacother. 2019 Sep;117:109191. doi: 10.1016/j.biopha.2019.109191. Epub 2019 Jul 4.
Normal wound repair is a dynamic and complex process involving multiple coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure during the repair process may cause chronic wounds or scar formation, which increase the financial burden of patients due to repetitive treatments and considerable medical expenditures, and affect their quality of life. Nowadays, extensive efforts have been made to develop novel therapeutics for wound repair. Genetic engineering technology, tissue engineering technology, stem cell-based therapy, physical and biochemical technology, and vacuum-assisted closure technique have been proposed to be beneficial for wound repair, and shown considerable potential for improving the rate and quality of wound healing and skin regeneration. However, challenges remain as applying these techniques. As the development of cell biology and molecular biology, the understanding of the mechanism under wound repair has gradually deepened. As the growth of interdisciplinary research on physics, chemistry, biology, tissue engineering, and materials, the concept and technique relating wound repair for clinical application have rapidly developed. This article reviews the latest progress on the mechanism and technique in wound repair.
正常的伤口修复是一个动态而复杂的过程，涉及多种生长因子、细胞因子、趋化因子和各种细胞的协调相互作用。修复过程中的任何失败都可能导致慢性伤口或瘢痕形成，由于反复治疗和大量医疗支出，这会增加患者的经济负担，并影响他们的生活质量。如今，人们已经做出了广泛的努力来开发用于伤口修复的新型疗法。基因工程技术、组织工程技术、基于干细胞的治疗、物理和生化技术以及真空辅助闭合技术已被证明有利于伤口修复，并显示出在提高伤口愈合和皮肤再生的速度和质量方面具有相当大的潜力。然而，在应用这些技术时仍然存在挑战。随着细胞生物学和分子生物学的发展，对伤口修复机制的理解逐渐加深。随着物理、化学、生物学、组织工程和材料等多学科研究的发展，与临床应用相关的伤口修复概念和技术也迅速发展。本文综述了伤口修复机制和技术的最新进展。
