• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

精油在促进伤口愈合中的应用。

Application of Essential Oil in Promoting Wound Healing.

机构信息

School of Traditional Medicine Materials Resource, Guangdong Pharmaceutical University, Yunfu 527325, China.

Yunfu Traditional Chinese Medicine Resources and Germplasm Resources Bank Management Center, Yunfu 527399, China.

出版信息

Molecules. 2024 Apr 30;29(9):2080. doi: 10.3390/molecules29092080.

DOI:10.3390/molecules29092080
PMID:38731569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11085404/
Abstract

Skin wounds, leading to infections and death, have a huge negative impact on healthcare systems around the world. Antibacterial therapy and the suppression of excessive inflammation help wounds heal. To date, the application of wound dressings, biologics and biomaterials (hydrogels, epidermal growth factor, stem cells, etc.) is limited due to their difficult and expensive preparation process. (Nees & T. Nees) Blume is an herb in traditional medicine, and its essential oil is rich in D-borneol, with antibacterial and anti-inflammatory effects. However, it is not clear whether essential oil has the function of promoting wound healing. This study analyzed 32 main components and their relative contents of essential oil using GC-MS. Then, network pharmacology was used to predict the possible targets of this essential oil in wound healing. We first proved this essential oil's effects in vitro and in vivo. essential oil could not only promote the proliferation and migration of skin stromal cells, but also promote M2-type polarization of macrophages while inhibiting the expression of pro-inflammatory cytokines. This study explored the possible mechanism by which essential oil promotes wound healing, providing a cheap and effective strategy for promoting wound healing.

摘要

皮肤创伤会导致感染和死亡，给全球的医疗体系带来巨大的负面影响。抗菌治疗和抑制过度炎症有助于伤口愈合。迄今为止，由于其制备过程复杂且昂贵，伤口敷料、生物制剂和生物材料（水凝胶、表皮生长因子、干细胞等）的应用受到限制。(Nees & T. Nees) Blume 是传统医学中的一种草药，其精油富含 D-龙脑，具有抗菌和抗炎作用。然而，尚不清楚精油是否具有促进伤口愈合的功能。本研究使用 GC-MS 分析了精油中的 32 种主要成分及其相对含量。然后，通过网络药理学预测该精油在伤口愈合中的可能作用靶点。我们首先在体外和体内证明了这种精油的作用。精油不仅可以促进皮肤基质细胞的增殖和迁移，还可以促进巨噬细胞 M2 型极化，同时抑制促炎细胞因子的表达。本研究探索了精油促进伤口愈合的可能机制，为促进伤口愈合提供了一种廉价有效的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/166bf9b4d28c/molecules-29-02080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/c2cb23232915/molecules-29-02080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/f54ac81c822b/molecules-29-02080-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/59a84aa5bf3b/molecules-29-02080-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/03b42e21afa5/molecules-29-02080-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/1af0401c5dbf/molecules-29-02080-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/9c50370625ff/molecules-29-02080-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/166bf9b4d28c/molecules-29-02080-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/c2cb23232915/molecules-29-02080-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/f54ac81c822b/molecules-29-02080-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/59a84aa5bf3b/molecules-29-02080-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/03b42e21afa5/molecules-29-02080-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/1af0401c5dbf/molecules-29-02080-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/9c50370625ff/molecules-29-02080-g006a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab50/11085404/166bf9b4d28c/molecules-29-02080-g007.jpg

相似文献

1
Application of Essential Oil in Promoting Wound Healing.精油在促进伤口愈合中的应用。
Molecules. 2024 Apr 30;29(9):2080. doi: 10.3390/molecules29092080.
2
Wound Healing Activity of the Essential Oil of , in Mice.贯叶连翘精油对小鼠的创伤愈合活性。
Molecules. 2020 Apr 14;25(8):1795. doi: 10.3390/molecules25081795.
3
Oxidative Stress-Mediated Repression of Virulence Gene Transcription and Biofilm Formation as Antibacterial Action of Essential Oil on .精油对 抗菌作用的机制：氧化应激介导的毒力基因转录和生物膜形成抑制。
Int J Mol Sci. 2024 Mar 6;25(5):3078. doi: 10.3390/ijms25053078.
4
Wound healing potential of oil extracted from Parrotiopsis jacquemontiana (Decne) Rehder.从 Parrotiopsis jacquemontiana（Decne）Rehder 中提取的油的伤口愈合潜力。
J Ethnopharmacol. 2019 May 23;236:354-365. doi: 10.1016/j.jep.2019.03.018. Epub 2019 Mar 14.
5
Essential oil-loaded lipid nanoparticles for wound healing.用于伤口愈合的载精油脂质纳米颗粒。
Int J Nanomedicine. 2017 Dec 27;13:175-186. doi: 10.2147/IJN.S152529. eCollection 2018.
6
Elucidation of the essential oil biosynthetic pathways in Cinnamomum burmannii through identification of six terpene synthases.通过鉴定六个萜烯合成酶阐明肉桂的精油生物合成途径。
Plant Sci. 2022 Apr;317:111203. doi: 10.1016/j.plantsci.2022.111203. Epub 2022 Feb 1.
7
Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum.土肉桂叶精油抗炎活性的研究
J Agric Food Chem. 2005 Sep 7;53(18):7274-8. doi: 10.1021/jf051151u.
8
Collagen sponge scaffolds loaded with Trichostatin A pretreated BMSCs-derived exosomes regulate macrophage polarization to promote skin wound healing.负载曲古抑菌素A预处理的骨髓间充质干细胞衍生外泌体的胶原海绵支架调节巨噬细胞极化以促进皮肤伤口愈合。
Int J Biol Macromol. 2024 Jun;269(Pt 2):131948. doi: 10.1016/j.ijbiomac.2024.131948. Epub 2024 Apr 28.
9
Antioxidant and Wound Healing Potential of Essential Oil from Citrus reticulata Peel and Its Chemical Characterization.柑橘皮精油的抗氧化和伤口愈合潜力及其化学成分分析。
Curr Pharm Biotechnol. 2021;22(8):1114-1121. doi: 10.2174/1389201021999200918102123.
10
Essential oil from Cinnamomum cassia Presl bark regulates macrophage polarization and ameliorates lipopolysaccharide-induced acute lung injury through TLR4/MyD88/NF-κB pathway.肉桂皮精油通过 TLR4/MyD88/NF-κB 通路调节巨噬细胞极化，改善脂多糖诱导的急性肺损伤。
Phytomedicine. 2024 Jul;129:155651. doi: 10.1016/j.phymed.2024.155651. Epub 2024 Apr 17.

引用本文的文献

1
Formulation, Characterization, Antibacterial Activity, Antioxidant Activity, and Safety Evaluation of Essential Oil Nanoemulsions Through High-Pressure Homogenization.通过高压均质法制备精油纳米乳液的配方、表征、抗菌活性、抗氧化活性及安全性评价
Antioxidants (Basel). 2024 Dec 30;14(1):33. doi: 10.3390/antiox14010033.

本文引用的文献

1
Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Medicinal Plants on Human Skin Fibroblasts.多步骤方法指向对九种药用植物水合物对人皮肤成纤维细胞的生物活性和安全性负责的化合物。
Antioxidants (Basel). 2023 Nov 9;12(11):1988. doi: 10.3390/antiox12111988.
2
Essential Oils: Chemistry and Pharmacological Activities.香精油：化学与药理学活动。
Biomolecules. 2023 Jul 18;13(7):1144. doi: 10.3390/biom13071144.
3
Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol.
比较不同立体化学构型龙脑（L-龙脑、D-龙脑和合成龙脑）的药理学活性和安全性。
Biomed Pharmacother. 2023 Aug;164:114668. doi: 10.1016/j.biopha.2023.114668. Epub 2023 Jun 13.
4
Exploiting the bioactive properties of essential oils and their potential applications in food industry.利用精油的生物活性特性及其在食品工业中的潜在应用。
Food Sci Biotechnol. 2023 Mar 24;32(7):885-902. doi: 10.1007/s10068-023-01287-0. eCollection 2023 Jun.
5
Pharmacologic effects approach of essential oils and their components on respiratory diseases.精油及其成分对呼吸系统疾病的药理作用研究方法。
J Ethnopharmacol. 2023 Mar 25;304:115962. doi: 10.1016/j.jep.2022.115962. Epub 2022 Dec 15.
6
Fabrication, In Vitro, and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing.桉叶油纳米乳凝胶的制备、体外及体内评价：一种新型伤口愈合范例
Pharmaceutics. 2022 Sep 19;14(9):1971. doi: 10.3390/pharmaceutics14091971.
7
Aligned electrospun poly(L-lactide) nanofibers facilitate wound healing by inhibiting macrophage M1 polarization via the JAK-STAT and NF-κB pathways.取向静电纺丝聚（L-丙交酯）纳米纤维通过 JAK-STAT 和 NF-κB 通路抑制巨噬细胞 M1 极化促进伤口愈合。
J Nanobiotechnology. 2022 Jul 26;20(1):342. doi: 10.1186/s12951-022-01549-9.
8
Natural essential oils: A promising strategy for treating cardio-cerebrovascular diseases.天然精油：治疗心脑血管疾病的有前途策略。
J Ethnopharmacol. 2022 Oct 28;297:115421. doi: 10.1016/j.jep.2022.115421. Epub 2022 Jun 2.
9
Elucidation of the essential oil biosynthetic pathways in Cinnamomum burmannii through identification of six terpene synthases.通过鉴定六个萜烯合成酶阐明肉桂的精油生物合成途径。
Plant Sci. 2022 Apr;317:111203. doi: 10.1016/j.plantsci.2022.111203. Epub 2022 Feb 1.
10
Chitosan-based hydrogels with injectable, self-healing and antibacterial properties for wound healing.壳聚糖基水凝胶具有可注射、自修复和抗菌性能，可用于伤口愈合。
Carbohydr Polym. 2022 Jan 15;276:118718. doi: 10.1016/j.carbpol.2021.118718. Epub 2021 Oct 2.