Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Nutr Cancer. 2020;72(4):554-567. doi: 10.1080/01635581.2019.1648694. Epub 2019 Aug 7.
Several studies have focused on chemical agents, tailored from natural edible products, used to prevent and treat various diseases. β-elemene is a well-known compound derived from that possesses a wide spectrum of anticancer properties under preclinical and clinical conditions. Several studies have demonstrated its inhibitory effect both in humans and animals with cancers. Numerous and experimental models have revealed that β-elemene can modulate multiple molecular pathways involved in carcinogenesis. In general, (1) β-elemene itself can inhibit and kill tumor cells through a variety of mechanisms, and (2) can synergistically enhance the effect of radiotherapy and/or chemotherapy, (3) also can regulate autoimmune in the treatment of tumors. In this article, we critically focused on the available scientific evidence discussing the use of β-elemene in cancer prevention, and its molecular targets and mechanisms of action in different types of cancer. In addition, we have discussed its sources, chemistry, bioavailability, and future research directions.
已有多项研究聚焦于从天然可食用产品中提取的化学试剂，旨在预防和治疗各种疾病。β-榄香烯是一种源于 的知名化合物，在临床前和临床条件下具有广泛的抗癌特性。多项研究表明，β-榄香烯对人类和动物癌症均具有抑制作用。大量临床前和临床试验模型揭示，β-榄香烯可调节致癌过程中涉及的多个分子通路。总体而言，（1）β-榄香烯本身可通过多种机制抑制和杀伤肿瘤细胞，（2）可协同增强放疗和/或化疗效果，（3）还可在治疗肿瘤时调节自身免疫。本文集中讨论了现有的科学证据，探讨了β-榄香烯在癌症预防中的应用，以及其在不同类型癌症中的分子靶点和作用机制。此外，还讨论了β-榄香烯的来源、化学特性、生物利用度和未来研究方向。
