Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
School of Biological Sciences, University of Auckland, Auckland, New Zealand.
Nutr Cancer. 2020;72(4):645-652. doi: 10.1080/01635581.2019.1648693. Epub 2019 Aug 7.
Medicinal mushrooms have been used for the treatment of diseases and general promotion of health for many centuries. Recent pharmacological research into medicinal mushrooms has identified various therapeutic properties, with applications in modern medicine. To evaluate the anti-cancer activities of () alcoholic extract in an in vivo setting. The anti-tumour effect of the extract was tested in a xenograft immune-compromised Rag-1 mouse model. This was followed by RT-PCR and metabolomics analyses. There were no observable differences in tumor growth between treated and non-treated groups. The bioactive components were not detected in the mouse plasma or the tumor site. The extract was poorly absorbed; this is likely due to the timing of treatment, dosage levels and modifications made to the extract where the alcohol-based solvent was replaced with water. This, in combination with fractionation studies which identified most anti-cancer compounds to be hydrophobic, largely explained the lack of anti-cancer activities in vivo.
药用蘑菇被用于治疗疾病和促进健康已有数个世纪。最近对药用蘑菇的药理学研究发现了各种治疗特性，可应用于现代医学。为了评估（）醇提物在体内环境中的抗癌活性。在异种移植免疫缺陷 Rag-1 小鼠模型中测试了提取物的抗肿瘤作用。随后进行了 RT-PCR 和代谢组学分析。在治疗组和未治疗组之间，肿瘤生长没有观察到差异。生物活性成分未在小鼠血浆或肿瘤部位检测到。提取物吸收不良；这可能是由于治疗时间、剂量水平以及对提取物的修改，其中酒精溶剂被水取代。这一点，再加上分馏研究确定大多数抗癌化合物是疏水性的，在很大程度上解释了体内缺乏抗癌活性的原因。
