Section of Clinical Biochemistry, University of Verona, Verona, Italy.
Section of Clinical Governance, Provincial Agency for Social and Sanitary Services, Trento, Italy.
Nutr Cancer. 2020;72(4):547-553. doi: 10.1080/01635581.2019.1650190. Epub 2019 Aug 7.
Kiwifruit consumption is associated with many favorable health benefits. This article is hence aimed to provide an overview on potential effects of kiwifruit on cancer development or progression. An electronic search was performed in Medline and Web of Science, for identifying original studies exploring the relationship between kiwifruit and cancer development or progression, both in vivo and in vitro. The following keywords were used: "Kiwifruit" OR "Kiwi" OR "" OR "," in combination with "cancer" OR "malignancy" OR "neoplasm." Overall, 58 items could be retrieved, fifty of which were excluded since they did not fulfilled all our search criteria. Eight studies (five in vitro studies, two human intervention trials, and one both in vivo and in human study) were finally included in this critical literature review. Taken together, the results of these published studies suggest that kiwifruit supplementation may be associated with direct and indirect anticancer effects, the former likely due to ascorbic acid-mediated reduction of DNA oxidative injury and cytotoxic effect on cancer cell lines, the latter more likely attributable to enhanced daily bowel movements and increased intestinal fecal content of lactic acid bacteria, which would finally contribute to lower the risk of malignancies, especially colorectal cancer.
猕猴桃的消费与许多有益健康的好处有关。本文旨在概述猕猴桃对癌症发展或进展的潜在影响。在 Medline 和 Web of Science 上进行了电子检索，以确定探索猕猴桃与癌症发展或进展之间关系的原始研究，包括体内和体外研究。使用了以下关键词：“猕猴桃”或“奇异果”或“”或“，”与“癌症”或“恶性肿瘤”或“肿瘤”相结合。总共可以检索到 58 项，其中 50 项由于不符合我们所有的搜索标准而被排除在外。最终纳入了八项研究（五项体外研究、两项人体干预试验和一项体内和人体研究）。这些已发表研究的结果表明，猕猴桃补充剂可能与直接和间接的抗癌作用有关，前者可能归因于抗坏血酸介导的 DNA 氧化损伤减少和对癌细胞系的细胞毒性作用，后者更可能归因于每日排便次数增加和肠道内乳酸细菌粪便含量增加，这最终有助于降低恶性肿瘤的风险，特别是结直肠癌的风险。
