Zhang Ming, Zhang Shaoqin, Shi Hao, Li Weidong, Wei Zhengliang
Department of Cardiothoracic Surgery, Shengzhou Renmin Hospital, Shaoxing, 312400, China.
Department of Cardiothoracic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China.
J Cardiothorac Surg. 2019 Aug 6;14(1):148. doi: 10.1186/s13019-019-0965-0.
Mediastinal lipoma/liposarcoma is a rare tumor of the mediastinum.
This article reported one case of giant anterior superior mediastinum well-differentiated liposarcoma involving the left thoracic cavity with symptom of dysphagia. The mediastinum liposarcoma was completely resected through a left thoracotomy. Histologic examination and molecular pathological test clarified the diagnosis as well-differentiated mediastinal liposarcoma. There has been no evidence of recurrence during the 8 months follow-up.
Molecular pathological examination of the MDM2, CDK4 and p16 gene in tumors provides the diagnostic gold standard in distinguishing well-differentiated liposarcoma from lipoma. Complete surgical resection is the first-line treatment choice for mediastinal lipoma/ liposarcoma.
纵隔脂肪瘤/脂肪肉瘤是一种罕见的纵隔肿瘤。
本文报道1例巨大前上纵隔高分化脂肪肉瘤累及左胸腔并伴有吞咽困难症状。通过左胸切口将纵隔脂肪肉瘤完整切除。组织学检查和分子病理检测明确诊断为高分化纵隔脂肪肉瘤。随访8个月期间无复发迹象。
肿瘤中MDM2、CDK4和p16基因的分子病理检查是鉴别高分化脂肪肉瘤与脂肪瘤的诊断金标准。完整手术切除是纵隔脂肪瘤/脂肪肉瘤的一线治疗选择。
