Issitt P D, Smith D L, McCollister L S, Wren M R, Ballas S K
American Red Cross Blood Services, South Florida Region, Miami.
Transfusion. 1988 Sep-Oct;28(5):439-43. doi: 10.1046/j.1537-2995.1988.28588337332.x.
It has been reported previously that genes that have been called Dc- represent a heterogeneous group and that some of them would better be described as Dc[e] and Dc(e). We have studied the blood of a black proposita and some of her family members and have concluded that she is homozygous for Dc(e). The form of Dc(e) present in this family makes all the Rh antigens of common occurrence for which we were able to test. In this respect, it differs markedly from another form of Dc(e), which is seen in individuals whose red cells lack a very common Rh antigen and who become immunized against that antigen. We suggest the term Dc(e)R17 for the gene present in the family studied; our results indicate that its products are: normal amounts of D, c, G, Hr0, and Rh29; reduced amounts of e and f; and markedly reduced amounts of hrS and hrB. The expression of some antigens encoded by Dc(e)R17 are quantitatively but not qualitatively different from the products of R0.
先前有报道称，被称为Dc-的基因代表一个异质群体，其中一些基因更适合被描述为Dc[e]和Dc(e)。我们研究了一名黑人先证者及其一些家庭成员的血液，得出结论她是Dc(e)纯合子。该家族中存在的Dc(e)形式产生了我们能够检测的所有常见Rh抗原。在这方面，它与另一种Dc(e)形式明显不同，后者见于红细胞缺乏一种非常常见的Rh抗原且针对该抗原产生免疫的个体。我们建议将所研究家族中存在的基因称为Dc(e)R17；我们的结果表明其产物为：正常量的D、c、G、Hr0和Rh29；减少量的e和f；以及显著减少量的hrS和hrB。Dc(e)R17编码的一些抗原的表达在数量上而非质量上与R0的产物不同。
