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阿克曼氏菌（Akkermansia muciniphila）可降低血脂和调节免疫，而不影响载脂蛋白 E*3-莱顿（APOE*3-Leiden）.CETP 小鼠的新生内膜形成。

Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice.

机构信息

Department of Human Genetics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.

出版信息

Mol Nutr Food Res. 2020 Aug;64(15):e1900732. doi: 10.1002/mnfr.201900732. Epub 2019 Aug 16.

DOI:10.1002/mnfr.201900732
PMID:31389129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7507188/
Abstract

SCOPE

Akkermansia muciniphila (A. muciniphila) is an intestinal commensal with anti-inflammatory properties both in the intestine and other organs. The aim is to investigate the effects of oral administration of A. muciniphila on lipid metabolism, immunity, and cuff-induced neointima formation in hyperlipidemic APOE*3-Leiden (E3L).CETP mice.

METHODS AND RESULTS

Hyperlipidemic male E3L.CETP mice are daily treated with 2 × 10 CFU A. muciniphila by oral gavage for 4 weeks and the effects are determined on plasma lipid levels, immune parameters, and cuff-induced neointima formation and composition. A. muciniphila administration lowers body weight and plasma total cholesterol and triglycerides levels. A. muciniphila influences the immune cell composition in mesenteric lymph nodes, as evident from an increased total B cell population, while reducing the total T cell and neutrophil populations. Importantly, A. muciniphila reduces the expression of the activation markers MHCII on dendritic cells and CD86 on B cells. A. muciniphila also increases whole blood ex vivo lipopolysaccharide-stimulated IL-10 release. Finally, although treatment with A. muciniphila improves lipid metabolism and immunity, it does not affect neointima formation or composition.

CONCLUSIONS

Four weeks of treatment with A. muciniphila exerts lipid-lowering and immunomodulatory effects, which are insufficient to inhibit neointima formation in hyperlipidemic E3L.CETP mice.

摘要

研究范围

黏蛋白阿克曼氏菌（A. muciniphila）是一种肠道共生菌，具有抗炎特性，既能在肠道内，也能在其他器官发挥作用。本研究旨在探究口服黏蛋白阿克曼氏菌对高脂血症 APOE*3-Leiden（E3L）载脂蛋白 CETP 小鼠的脂代谢、免疫和套管诱导的新生内膜形成的影响。

方法和结果

高脂血症雄性 E3L.CETP 小鼠每天经口灌胃 2×10 CFU 黏蛋白阿克曼氏菌 4 周，检测黏蛋白阿克曼氏菌对血浆脂质水平、免疫参数以及套管诱导的新生内膜形成和组成的影响。黏蛋白阿克曼氏菌给药可降低体重和血浆总胆固醇及甘油三酯水平。黏蛋白阿克曼氏菌影响肠系膜淋巴结免疫细胞组成，总 B 细胞群体增加，而总 T 细胞和中性粒细胞群体减少。重要的是，黏蛋白阿克曼氏菌降低了树突状细胞上 MHCII 和 B 细胞上 CD86 的激活标志物表达。黏蛋白阿克曼氏菌还增加了全血体外脂多糖刺激的 IL-10 释放。尽管黏蛋白阿克曼氏菌治疗改善了脂代谢和免疫，但它并不影响新生内膜的形成或组成。

结论

黏蛋白阿克曼氏菌治疗 4 周可降低血脂和调节免疫，但不足以抑制高脂血症 E3L.CETP 小鼠的新生内膜形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/61111c45486f/MNFR-64-1900732-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/27cfd219063d/MNFR-64-1900732-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/a37990ee2c65/MNFR-64-1900732-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/f1ea087f572e/MNFR-64-1900732-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/61111c45486f/MNFR-64-1900732-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/27cfd219063d/MNFR-64-1900732-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/8699899cca00/MNFR-64-1900732-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/caa50b64b391/MNFR-64-1900732-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/a37990ee2c65/MNFR-64-1900732-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/f1ea087f572e/MNFR-64-1900732-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b77/7507188/61111c45486f/MNFR-64-1900732-g005.jpg

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