Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom.
Physiology (Bethesda). 2019 Sep 1;34(5):314-326. doi: 10.1152/physiol.00009.2019.
Athletes are prone to supraventricular rhythm disturbances including sinus bradycardia, heart block, and atrial fibrillation. Mechanistically, this is attributed to high vagal tone and cardiac electrical and structural remodeling. Here, we consider the supporting evidence for these three pro-arrhythmic mechanisms in athletic human cohorts and animal models, featuring current controversies, emerging data, and future directions of relevance to the translational research agenda.
运动员易发生室上性节律紊乱，包括窦性心动过缓、心脏传导阻滞和心房颤动。从机制上讲，这归因于迷走神经张力增高以及心脏电重构和结构重构。在此，我们考虑了在竞技人类队列和动物模型中这三种致心律失常机制的支持证据，重点介绍了当前的争议、新出现的数据以及与转化研究计划相关的未来方向。
