Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou City, Sichuan Province 646000, P. R. China.
J Mater Chem B. 2019 Aug 7;7(31):4751-4757. doi: 10.1039/c9tb00882a.
We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.
我们开发了一种新型的纳米药物肿瘤靶向特性评价方法，基于近红外荧光成像，建立了平均肿瘤靶向指数（average TTI）和“肿瘤靶向指数-时间曲线下面积”（AUTC）作为纳米药物肿瘤靶向的指标，有助于实时监测体内靶向能力和肿瘤变化，无需处死动物。
