基于体内近红外荧光成像的纳米药物肿瘤靶向特性的非侵入性评价方法。
A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging.
机构信息
Department of Pharmaceutics, School of Pharmacy, Southwest Medical University, Luzhou City, Sichuan Province 646000, P. R. China.
出版信息
J Mater Chem B. 2019 Aug 7;7(31):4751-4757. doi: 10.1039/c9tb00882a.
Abstract
We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.
摘要
我们开发了一种新型的纳米药物肿瘤靶向特性评价方法，基于近红外荧光成像，建立了平均肿瘤靶向指数（average TTI）和“肿瘤靶向指数-时间曲线下面积”（AUTC）作为纳米药物肿瘤靶向的指标，有助于实时监测体内靶向能力和肿瘤变化，无需处死动物。
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