Department of Medical Informatics, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
Department of Paediatrics and Adolescent Medicine, Universitätsklinikum Erlangen, Erlangen, Germany.
Appl Clin Inform. 2019 Aug;10(4):570-579. doi: 10.1055/s-0039-1693714. Epub 2019 Aug 7.
Drug therapy in pediatric patients is a complex process. Children are subject to continuous growth and variation in drug-metabolizing enzyme activity, requiring continuous adaption of dosages. In Germany, currently no publicly available database exists that provides evidence-based information on drug dosages in pediatrics. For local drug dosing support, a prototype database has been developed within the Children's Hospital, Erlangen. A user-centered development process was initiated to establish an online platform for evidence-based dosing recommendations, as well as pharmacological and pharmaceutical drug information in pediatrics.
The objectives of the study were to survey the demand for such a platform and to assess the usability of the different versions of the developed system.
The developed prototype was evaluated in a pluralistic walkthrough with prospective end users. After a redesign, the second prototype of the online platform underwent an online usability testing based on a tailored questionnaire and the System Usability Scale (SUS) ( = 12).
Eleven of 12 participants expressed a demand for an online platform for pediatric dosing recommendations. The majority of the participants requested the integration of extended features, such as drug-drug interaction alerts, or information on adverse effects, pharmacokinetics, and pharmacodynamics. Particularly noteworthy is the demand for an online calculator; 5 of a total of 15 participants explicitly requested a calculator for dosages (based on age, weight, body surface) and glomerular filtration rate. The usability of the second prototype was rated "good to excellent" with a median SUS of 81.25.
Local domain experts demand an online platform for pediatric dosing recommendations. The application of the user-centered design approach enabled the development of a prototype suitable for practical use. Multiple additional required functionalities have been identified, whereby the importance of an online calculator for patient-individual dosing recommendations was particularly emphasized.
儿科患者的药物治疗是一个复杂的过程。儿童的药物代谢酶活性持续增长和变化，需要不断调整剂量。在德国，目前没有公开的数据库提供儿科药物剂量的循证信息。为了提供本地药物剂量支持，埃尔兰根儿童医院开发了一个原型数据库。为了建立一个基于证据的儿科药物剂量建议以及药理学和药物信息的在线平台，启动了一个以用户为中心的开发过程。
本研究的目的是调查对这样一个平台的需求，并评估开发系统的不同版本的可用性。
采用前瞻性终用户的多元演练对开发的原型进行评估。在重新设计后，在线平台的第二个原型基于定制问卷和系统可用性量表（SUS）（ = 12）进行在线可用性测试。
12 名参与者中有 11 名表达了对儿科剂量推荐在线平台的需求。大多数参与者要求集成扩展功能，如药物相互作用警报，或关于不良反应、药代动力学和药效学的信息。特别值得注意的是对在线计算器的需求；总共 15 名参与者中有 5 名明确要求剂量计算器（基于年龄、体重、体表面积）和肾小球滤过率。第二个原型的可用性被评为“好到极好”，中位数 SUS 为 81.25。
本地领域专家需要一个儿科剂量推荐的在线平台。用户为中心的设计方法的应用使适合实际使用的原型得以开发。已经确定了多个额外的所需功能，其中强调了用于患者个体化剂量推荐的在线计算器的重要性。
