Kiyani Amber, Sohail Kanwal, Saeed Muhammad Humza Bin
Islamic International Dental Hospital, Islamabad, Pakistan.
J Dermatolog Treat. 2021 May;32(3):367-371. doi: 10.1080/09546634.2019.1654072. Epub 2019 Aug 29.
This study documented the response of erosive oral lichen planus (OLP) to exclusive treatment with 0.1% topical tacrolimus over a 12-month period or until the patient became unresponsive to therapy.
A retrospective cohort design was used to acquire data on 12 patients with recalcitrant OLP that were prescribed 0.1% tacrolimus. These patients were prescribed 0.1% tacrolimus after failing to respond to conventional corticosteroid therapy. Information about their response to medication initially and on flare ups were included in this study.
The sample consisted of nine women and three men. All patients were given 0.1% tacrolimus to be applied 3 times a day. Two patients did not respond to the treatment at all, 4 patients showed partial response to tacrolimus treatment. Six patients showed complete initial response to treatment.
50% of our patients showed a suboptimal response to 0.1% tacrolimus use for erosive OLP, thus, suggesting that in some cases 0.1% tacrolimus may be an ineffective option for managing erosive OLP.
本研究记录了糜烂性口腔扁平苔藓（OLP）在为期12个月的时间内或直至患者对治疗无反应时接受0.1%外用他克莫司单一治疗的反应。
采用回顾性队列设计获取12例顽固性OLP患者的数据，这些患者被处方使用0.1%他克莫司。这些患者在对传统皮质类固醇治疗无反应后被处方使用0.1%他克莫司。本研究纳入了他们最初对药物的反应以及病情复发的信息。
样本包括9名女性和3名男性。所有患者均接受0.1%他克莫司治疗，每天涂抹3次。2例患者对治疗完全无反应，4例患者对他克莫司治疗有部分反应。6例患者最初对治疗有完全反应。
我们的患者中有50%对使用0.1%他克莫司治疗糜烂性OLP的反应欠佳，因此表明在某些情况下，0.1%他克莫司可能不是治疗糜烂性OLP的有效选择。
