Tobelem G, Cariou R, Camez A
Department of Angiohematology, Hôpital Lariboisière, Paris, France.
Blood Rev. 1987 Mar;1(1):21-4. doi: 10.1016/0268-960x(87)90015-4.
The lupus anticoagulant is usually found in the plasma of patients with systemic lupus erythematosus. Lupus anticoagulants are antibodies to phospholipids and probably to phosphodiester-linked phosphate groups. A high frequency of thrombotic events in patients with lupus anticoagulant has been reported. Nevertheless the pathogenesis of thrombosis in these patients remains unknown. Endothelium which plays a key role in the antithrombogenic-thrombogenic balance could be a target for the lupus anticoagulant and alterations of some endothelial-cell functions could be responsible for the thrombotic events. The effects of the lupus anticoagulant on the phospholipids of the protein C-thrombomodulin complex may be important although evidence of such a reaction in vivo is awaited.
狼疮抗凝物通常在系统性红斑狼疮患者的血浆中被发现。狼疮抗凝物是针对磷脂以及可能针对磷酸二酯连接的磷酸基团的抗体。已有报道称狼疮抗凝物患者发生血栓事件的频率较高。然而，这些患者血栓形成的发病机制仍不清楚。在内皮抗血栓形成-血栓形成平衡中起关键作用的内皮可能是狼疮抗凝物的作用靶点，一些内皮细胞功能的改变可能是血栓事件的原因。尽管仍有待体内这种反应的证据，但狼疮抗凝物对蛋白C-血栓调节蛋白复合物磷脂的影响可能很重要。
