• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

透明质酸-泊洛沙姆水凝胶对皮肤伤口愈合的影响：体外和体内研究

Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies.

作者信息

Li Xiaojuan, Li Aimin, Feng Fan, Jiang Qiyu, Sun Huiwei, Chai Yantao, Yang Ruichuang, Wang Zhijie, Hou Jun, Li Ruisheng

机构信息

Research Center for Clinical and Translational Medicine Fifth Medical Center General Hospital of Chinese PLA Beijing People's Republic of China.

Department of Rheumatology and Immunology Fifth Hospital of Qingdao City Qingdao Shandong Province People's Republic of China.

出版信息

Animal Model Exp Med. 2019 Apr 30;2(2):107-113. doi: 10.1002/ame2.12067. eCollection 2019 Jun.

DOI:10.1002/ame2.12067
PMID:31392303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6600631/
Abstract

BACKGROUND

Recent research into skin injury and wound healing has focused mainly on post-trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing.

METHODS

In the present work, we prepared a hyaluronic acid-poloxamer (HA-POL) hydrogel and tested the therapeutic effect of the hydrogel on skin-wound healing.

RESULTS

The HA-POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA-POL hydrogel promoted skin-wound healing and increased protein accumulation in the wound area. HA-POL hydrogel allowed greater air permeability than Band-aid, a typical wound covering. Results from transwell assays showed that the HA-POL hydrogel effectively isolated skin-wounds from bacterial invasion.

CONCLUSION

This work demonstrates the advantages of using HA-POL gel materials in the treatment of cutaneous wounds.

摘要

背景

近期对皮肤损伤和伤口愈合的研究主要集中在创伤后止血、感染预防、真皮再生和血管生成方面。然而，对透气性和防止水分流失的关注较少，而这在损伤愈合中也起着重要作用。

方法

在本研究中，我们制备了一种透明质酸-泊洛沙姆（HA-POL）水凝胶，并测试了该水凝胶对皮肤伤口愈合的治疗效果。

结果

HA-POL水凝胶在接近体温的30°C下从溶胶转变为凝胶，具有稳定的保湿性能。HA-POL水凝胶促进皮肤伤口愈合，并增加伤口区域的蛋白质积累。HA-POL水凝胶的透气性比典型的伤口覆盖物创可贴更好。Transwell试验结果表明，HA-POL水凝胶有效地隔离皮肤伤口，防止细菌入侵。

结论

这项工作证明了使用HA-POL凝胶材料治疗皮肤伤口的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/6d8d0babb4db/AME2-2-107-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/d2b05a723d81/AME2-2-107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/673a672afa3c/AME2-2-107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/c274da04f54f/AME2-2-107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/2ab3892800d2/AME2-2-107-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/2d28106e2b96/AME2-2-107-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/6d8d0babb4db/AME2-2-107-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/d2b05a723d81/AME2-2-107-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/673a672afa3c/AME2-2-107-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/c274da04f54f/AME2-2-107-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/2ab3892800d2/AME2-2-107-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/2d28106e2b96/AME2-2-107-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68c8/6600631/6d8d0babb4db/AME2-2-107-g006.jpg

相似文献

1
Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies.透明质酸-泊洛沙姆水凝胶对皮肤伤口愈合的影响：体外和体内研究
Animal Model Exp Med. 2019 Apr 30;2(2):107-113. doi: 10.1002/ame2.12067. eCollection 2019 Jun.
2
[Preparation and roles of sliver-loaded viscous hydrogel in healing of full-thickness skin defect wounds with bacterial colonization in mice].[载银粘性水凝胶在小鼠伴有细菌定植的全层皮肤缺损创面愈合中的制备及作用]
Zhonghua Shao Shang Za Zhi. 2021 Nov 20;37(11):1036-1047. doi: 10.3760/cma.j.cn501120-20210906-00304.
3
Salvianolic-Acid-B-Loaded HA Self-Healing Hydrogel Promotes Diabetic Wound Healing through Promotion of Anti-Inflammation and Angiogenesis.载丹酚酸 B 的透明质酸自修复水凝胶通过促进抗炎和血管生成促进糖尿病伤口愈合。
Int J Mol Sci. 2023 Apr 6;24(7):6844. doi: 10.3390/ijms24076844.
4
Conformable hyaluronic acid hydrogel delivers adipose-derived stem cells and promotes regeneration of burn injury.可顺应性透明质酸水凝胶递送脂肪来源干细胞并促进烧伤创面再生。
Acta Biomater. 2020 May;108:56-66. doi: 10.1016/j.actbio.2020.03.040. Epub 2020 Apr 3.
5
Copper Sulfide Nanoparticles-Incorporated Hyaluronic Acid Injectable Hydrogel With Enhanced Angiogenesis to Promote Wound Healing.负载硫化铜纳米颗粒的透明质酸可注射水凝胶具有增强的血管生成作用以促进伤口愈合。
Front Bioeng Biotechnol. 2020 May 8;8:417. doi: 10.3389/fbioe.2020.00417. eCollection 2020.
6
Development of Poloxamer Hydrogels Containing Antibacterial Guanidine-Based Polymers for Healing of Full-Thickness Skin Wound.载抗菌胍基聚合物的泊洛沙姆水凝胶的开发用于全层皮肤伤口愈合。
ACS Biomater Sci Eng. 2021 Sep 13;7(9):4557-4568. doi: 10.1021/acsbiomaterials.1c00600. Epub 2021 Aug 23.
7
Fetal milieu-simulating hyaluronic acid-dopamine-chondroitin sulfate hydrogel promoting angiogenesis and hair regeneration for wound healing.模拟胎儿环境的透明质酸-多巴胺-硫酸软骨素水凝胶促进血管生成和毛发再生以促进伤口愈合。
Int J Biol Macromol. 2023 Sep 1;248:125739. doi: 10.1016/j.ijbiomac.2023.125739. Epub 2023 Jul 7.
8
Injectable adaptive self-healing hyaluronic acid/poly (γ-glutamic acid) hydrogel for cutaneous wound healing.用于皮肤伤口愈合的可注射自适应自修复透明质酸/聚（γ-谷氨酸）水凝胶。
Acta Biomater. 2021 Jun;127:102-115. doi: 10.1016/j.actbio.2021.03.057. Epub 2021 Apr 1.
9
In situ hydrogel capturing nitric oxide microbubbles accelerates the healing of diabetic foot.原位水凝胶捕获一氧化氮微泡加速糖尿病足愈合。
J Control Release. 2022 Oct;350:93-106. doi: 10.1016/j.jconrel.2022.08.018. Epub 2022 Aug 17.
10
[Effects of temperature-sensitive hydroxybutyl chitosan hydrogel on wound healing of full-thickness skin defect in rats].[温度敏感型羟丁基壳聚糖水凝胶对大鼠全层皮肤缺损创面愈合的影响]
Zhonghua Shao Shang Za Zhi. 2021 Dec 20;37(12):1166-1174. doi: 10.3760/cma.j.cn501120-20200927-00424.

引用本文的文献

1
Topical Meglumine Antimoniate Gel for Cutaneous Leishmaniasis: Formulation, Evaluation, and In Silico Insights.用于皮肤利什曼病的局部用葡甲胺锑酸盐凝胶：制剂、评价及计算机模拟分析
Gels. 2025 Aug 1;11(8):601. doi: 10.3390/gels11080601.
2
Development and In Vitro Characterization of Azithromycin-PLGA Nanoparticles Loaded Thermoresponsive Hydrogels: A Quality by Design Approach Toward Intra-Articular Delivery of Macrolides.载阿奇霉素的聚乳酸-羟基乙酸共聚物纳米粒温敏水凝胶的研制及其体外特性：基于质量源于设计理念的大环内酯类药物关节腔内给药研究
AAPS PharmSciTech. 2025 Jun 26;26(6):171. doi: 10.1208/s12249-025-03170-z.
3
Engineered Bacteriophage-Polymer Nanoassemblies for Treatment of Wound Biofilm Infections.

本文引用的文献

1
Silver nanoparticles increase connexin43-mediated gap junctional intercellular communication in HaCaT cells through activation of reactive oxygen species and mitogen-activated protein kinase signal pathway.银纳米粒子通过激活活性氧和丝裂原活化蛋白激酶信号通路增加 HaCaT 细胞间隙连接细胞间通讯蛋白 43 的表达。
J Appl Toxicol. 2018 Apr;38(4):564-574. doi: 10.1002/jat.3563. Epub 2017 Dec 13.
2
Efficacy of the dual controlled release of HGF and bFGF impregnated with a collagen/gelatin scaffold.胶原蛋白/明胶支架负载的HGF和bFGF双重控释的疗效。
J Surg Res. 2018 Jan;221:173-182. doi: 10.1016/j.jss.2017.08.051. Epub 2017 Sep 25.
3
工程噬菌体-聚合物纳米组装体用于治疗伤口生物膜感染。
ACS Nano. 2024 Oct 1;18(39):26928-26936. doi: 10.1021/acsnano.4c08671. Epub 2024 Sep 17.
4
Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair.基于透明质酸的水凝胶与人间充质基质细胞分泌组整合用于糖尿病溃疡修复的局部应用。
Regen Ther. 2024 Jul 27;26:520-532. doi: 10.1016/j.reth.2024.07.008. eCollection 2024 Jun.
5
Research progress related to thermosensitive hydrogel dressings in wound healing: a review.温敏水凝胶敷料在伤口愈合中的研究进展：综述
Nanoscale Adv. 2023 Oct 26;5(22):6017-6037. doi: 10.1039/d3na00407d. eCollection 2023 Nov 7.
6
Investigation and Characterization of Factors Affecting Rheological Properties of Poloxamer-Based Thermo-Sensitive Hydrogel.泊洛沙姆基热敏水凝胶流变学性质影响因素的研究与表征
Polymers (Basel). 2022 Dec 7;14(24):5353. doi: 10.3390/polym14245353.
7
Recent Progress on Hyaluronan-Based Products for Wound Healing Applications.用于伤口愈合的透明质酸基产品的最新进展
Pharmaceutics. 2022 Oct 19;14(10):2235. doi: 10.3390/pharmaceutics14102235.
8
Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders.透明质酸支架在神经系统相关疾病的局部治疗中的应用。
Int J Mol Sci. 2022 Oct 12;23(20):12174. doi: 10.3390/ijms232012174.
9
Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration.聚合物水凝胶支架：皮肤组织工程与再生
Adv Pharm Bull. 2022 May;12(3):437-448. doi: 10.34172/apb.2022.069. Epub 2021 Sep 14.
10
Natural Biopolymers as Additional Tools for Cell Microencapsulation Applied to Cellular Therapy.天然生物聚合物作为细胞微囊化的附加工具应用于细胞治疗。
Polymers (Basel). 2022 Jun 29;14(13):2641. doi: 10.3390/polym14132641.
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo.
HOTAIR 通过介导 EZH2 和 DNMT1 的相互调控促进重楼皂苷 I 抑制去势抵抗性前列腺癌细胞的体外和体内生长。
Biochim Biophys Acta Gen Subj. 2018 Mar;1862(3):589-599. doi: 10.1016/j.bbagen.2017.12.001. Epub 2017 Dec 6.
4
Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability.用于缬沙坦的具有改善的溶出度和生物利用度的过饱和自微乳化药物递送系统的固体剂型。
Oncotarget. 2017 Oct 9;8(55):94297-94316. doi: 10.18632/oncotarget.21691. eCollection 2017 Nov 7.
5
A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage.一种新型的双轴机械加载生物反应器系统可增强组织工程化人软骨的性能。
Sci Rep. 2017 Dec 5;7(1):16997. doi: 10.1038/s41598-017-16523-x.
6
Comparison of perioperative complications of pedicled island flap in reconstruction of extremities.带蒂岛状皮瓣修复四肢的围手术期并发症比较
J Surg Res. 2017 Dec;220:94-104. doi: 10.1016/j.jss.2017.06.089. Epub 2017 Jul 25.
7
Skin and Its Regenerative Powers: An Alliance between Stem Cells and Their Niche.皮肤及其再生能力：干细胞与其微环境之间的协同作用
Dev Cell. 2017 Nov 20;43(4):387-401. doi: 10.1016/j.devcel.2017.10.001.
8
The effects of artocarpin on wound healing: in vitro and in vivo studies.ART 对创伤愈合的影响：体内外研究。
Sci Rep. 2017 Nov 15;7(1):15599. doi: 10.1038/s41598-017-15876-7.
9
Effects of low-dose epinephrine on perioperative hemostasis and inflammatory reaction in major surgical operations: a randomized clinical trial.小剂量肾上腺素对大手术围手术期止血和炎症反应的影响：一项随机临床试验。
J Thromb Haemost. 2018 Jan;16(1):74-82. doi: 10.1111/jth.13896. Epub 2017 Dec 1.
10
Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK-dependent mechanisms.吡格列酮通过调节 AMPK 依赖机制中的 Th17/Treg 平衡来稳定动脉粥样硬化斑块。
Cardiovasc Diabetol. 2017 Oct 30;16(1):140. doi: 10.1186/s12933-017-0623-6.