透明质酸-泊洛沙姆水凝胶对皮肤伤口愈合的影响：体外和体内研究
Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies.
作者信息
Li Xiaojuan, Li Aimin, Feng Fan, Jiang Qiyu, Sun Huiwei, Chai Yantao, Yang Ruichuang, Wang Zhijie, Hou Jun, Li Ruisheng
机构信息
Research Center for Clinical and Translational Medicine Fifth Medical Center General Hospital of Chinese PLA Beijing People's Republic of China.
Department of Rheumatology and Immunology Fifth Hospital of Qingdao City Qingdao Shandong Province People's Republic of China.
出版信息
Animal Model Exp Med. 2019 Apr 30;2(2):107-113. doi: 10.1002/ame2.12067. eCollection 2019 Jun.
BACKGROUND
Recent research into skin injury and wound healing has focused mainly on post-trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing.
METHODS
In the present work, we prepared a hyaluronic acid-poloxamer (HA-POL) hydrogel and tested the therapeutic effect of the hydrogel on skin-wound healing.
RESULTS
The HA-POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA-POL hydrogel promoted skin-wound healing and increased protein accumulation in the wound area. HA-POL hydrogel allowed greater air permeability than Band-aid, a typical wound covering. Results from transwell assays showed that the HA-POL hydrogel effectively isolated skin-wounds from bacterial invasion.
CONCLUSION
This work demonstrates the advantages of using HA-POL gel materials in the treatment of cutaneous wounds.
背景
近期对皮肤损伤和伤口愈合的研究主要集中在创伤后止血、感染预防、真皮再生和血管生成方面。然而，对透气性和防止水分流失的关注较少，而这在损伤愈合中也起着重要作用。
方法
在本研究中，我们制备了一种透明质酸-泊洛沙姆（HA-POL）水凝胶，并测试了该水凝胶对皮肤伤口愈合的治疗效果。
结果
HA-POL水凝胶在接近体温的30°C下从溶胶转变为凝胶，具有稳定的保湿性能。HA-POL水凝胶促进皮肤伤口愈合，并增加伤口区域的蛋白质积累。HA-POL水凝胶的透气性比典型的伤口覆盖物创可贴更好。Transwell试验结果表明，HA-POL水凝胶有效地隔离皮肤伤口，防止细菌入侵。
结论
这项工作证明了使用HA-POL凝胶材料治疗皮肤伤口的优势。
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