Ocular Immunology and Uveitis Service, Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute San Raffaele , Milan, Italy.
Ocul Immunol Inflamm. 2020 May 18;28(4):637-646. doi: 10.1080/09273948.2019.1616769. Epub 2019 Aug 8.
To identify main qualitative and quantitative changes by spectral-domain optical coherence tomography (SD-OCT) in eyes with vitreoretinal lymphoma (VRL) shifting form active to remission phase, after intravitreal rituximab (IVR). SD-OCT scans retrospectively assessed for: hyperreflective retinal dots (HRD), intraretinal infiltration, subretinal infiltration, outer retina (OR) fuzzy borders, and pigment epithelium detachments (PED).Central macular thickness (CMT) and choroidal thickness (CT) were measured. These features were examined in active and in remission phase. Eighteen eyes of nine patients enrolled. Patients received 5.3 ± 2.1 IVR according to a 2-weekly or monthly schedule. In remission phase, presence of HRD ( = 0.02), intraretinal infiltration ( = 0.02), OR fuzzy borders ( = 0.01) significantly reduced. Treatment frequency did not influence rate of disappearance of these features. CMT ( = 0.04) and CT ( = 0.004) became thinner. Signs referable to lymphoma-induced inflammation (CMT, CT, HRD) and infiltration (intraretinal infiltrates, OR fuzzy borders) decreased in remission phase. Further comparative studies needed to identify the specific role of IVR in inducing these changes.
为了识别玻璃体内注射利妥昔单抗（IVR）后从活动性转变为缓解期的眼内视网膜淋巴瘤（VRL）的光谱域光相干断层扫描（SD-OCT）的主要定性和定量变化，对 SD-OCT 扫描进行回顾性评估：视网膜高反射点（HRD）、视网膜内浸润、视网膜下浸润、外视网膜（OR）模糊边界和色素上皮脱离（PED）。测量中心视网膜厚度（CMT）和脉络膜厚度（CT）。在活动性和缓解期检查这些特征。纳入 9 例患者的 18 只眼。患者根据每周或每月的方案接受 5.3±2.1 次 IVR。在缓解期，HRD（ = 0.02）、视网膜内浸润（ = 0.02）、OR 模糊边界（ = 0.01）显著减少。治疗频率并不影响这些特征消失的速度。CMT（ = 0.04）和 CT（ = 0.004）变薄。与淋巴瘤引起的炎症（CMT、CT、HRD）和浸润（视网膜内浸润、OR 模糊边界）相关的迹象在缓解期减少。需要进一步的比较研究来确定 IVR 在诱导这些变化中的具体作用。
