Viegas O A, Singh K, Koh S, Singh P, Ratnam S S
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Contraception. 1988 Sep;38(3):313-23. doi: 10.1016/0010-7824(88)90103-5.
A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using the levonorgestrel subdermal implants NORPLANT for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicate that these subjects may have an increased predisposition to thrombosis as evidenced by significant increase in platelet count and aggregability. The results also show that NORPLANT acceptors may have an enhanced potential for hypercoagulation - with a significant shortening of their Prothrombin Time and Activated Partial Thromboplastin Time and increases in Factors V and X. As previously documented, mean values for haemoglobin and haematocrit were significantly elevated by the end of 1 year. A number of other parameters achieved statistically significant differences by the end of 1 year but these were probably due to the large sample size involved and were therefore not likely to be of much clinical importance.
对100名使用左炔诺孕酮皮下植入剂诺普兰进行避孕的新加坡接受者进行了凝血参数的纵向研究。在使用1年结束时，这项正在进行的研究结果表明，这些受试者可能更容易发生血栓形成，血小板计数和聚集性显著增加证明了这一点。结果还表明，使用诺普兰的接受者可能具有增强的高凝潜力——凝血酶原时间和活化部分凝血活酶时间显著缩短，因子V和因子X增加。如先前记录的那样，血红蛋白和血细胞比容的平均值在1年结束时显著升高。到1年结束时，许多其他参数也达到了统计学上的显著差异，但这可能是由于样本量较大，因此不太可能具有太大的临床意义。
