Singh K, Viegas O A, Koh S, Singh P, Ratnam S S
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital.
Contraception. 1989 Feb;39(2):155-64. doi: 10.1016/s0010-7824(89)80004-6.
A longitudinal study of coagulation parameters was carried out on 100 Singaporean acceptors using Norplant-2 rods for contraceptive purposes. At the end of 2 years of use, results from this study show a return of platelet count to preinsertion level while platelet aggregation remained significantly enhanced. Thus the net effect of these two changes on an increased tendency for thrombosis needs further evaluation. The PT and APTT continued to remain persistently shortened during the period of use. There was also a general fall in fibrinogen and most other coagulation factors during the two years of use. Thus, again, the net effect of these two changes on the exposed potential for hypercoagulation at the end of the first year needs further evaluation throughout the five years of Norplant-2 use.
对100名使用诺普兰-2型避孕棒进行避孕的新加坡受术者进行了凝血参数的纵向研究。使用2年后，该研究结果显示血小板计数恢复到植入前水平，而血小板聚集仍显著增强。因此，这两种变化对血栓形成倾向增加的净效应需要进一步评估。在使用期间，凝血酶原时间（PT）和活化部分凝血活酶时间（APTT）持续显著缩短。在使用的两年中，纤维蛋白原和大多数其他凝血因子也普遍下降。因此，同样，在诺普兰-2型避孕棒使用的五年期间，这两种变化对第一年年底高凝状态潜在风险的净效应需要进一步评估。
