Singh K, Viegas O A, Koh S C, Ratnam S S
Department of Obstetrics and Gynaecology, National University of Singapore, National University Hospital, Singapore.
Contraception. 1992 Mar;45(3):203-19. doi: 10.1016/0010-7824(92)90065-2.
This study describes the effects of Norplant on haemostatic function after 5 years of use in 97 women. There was a decrease in vitamin-K dependent Factors II, V, VII and reduction in fibrinolytic activity at 2 and 4 years of use. Increased platelet numbers and accelerated platelet aggregation were found throughout the 5 years of Norplant use, whilst raised alpha 2-Macroglobulin (a2-M) and antithrombin III (ATIII) antigen level were observed for up to 4 years of use. Prolonged Norplant use does not appear to activate the coagulation system and does not enhance a state of hypercoagulation.
本研究描述了97名女性使用诺普兰5年后对止血功能的影响。使用2年和4年时，维生素K依赖因子II、V、VII减少，纤维蛋白溶解活性降低。在使用诺普兰的5年中，血小板数量增加且血小板聚集加速，同时在使用长达4年的时间里观察到α2-巨球蛋白（a2-M）和抗凝血酶III（ATIII）抗原水平升高。长期使用诺普兰似乎不会激活凝血系统，也不会增强高凝状态。
