Singh K, Viegas O A, Koh S, Singh P, Ratnam S S
Department of Obstetrics and Gynaecology, National University of Singapore.
Contraception. 1988 Oct;38(4):441-51. doi: 10.1016/0010-7824(88)90085-6.
A longitudinal study of coagulation parameters was carried out on 100 Singapore acceptors using the levonorgestrel subdermal implants Norplant-2 rods for contraceptive purposes. At the end of 1 year of use, results from this on-going study indicates that these acceptors have an enhanced potential for hypercoagulation with a significant shortening of their prothrombin time and activated partial thromboplastin time. They also have an increased predisposition to thrombosis as evidenced by significant increases in platelet count and aggregability. A number of other parameters achieved statistically significant differences by the end of one year but since the results were within the normal accepted range, they were therefore unlikely to be of much clinical importance.
对100名使用左炔诺孕酮皮下植入剂Norplant-2棒进行避孕的新加坡接受者进行了凝血参数的纵向研究。在使用1年后，这项正在进行的研究结果表明，这些接受者发生高凝的可能性增加，凝血酶原时间和活化部分凝血活酶时间显著缩短。他们发生血栓形成的易感性也增加，表现为血小板计数和聚集性显著增加。到1年末，许多其他参数也出现了具有统计学意义的差异，但由于结果在正常可接受范围内，因此它们不太可能具有太大的临床重要性。
