Mehrotra Ravi, Vasstrand Endre Normann, Ibrahim Salah Osman
Department of Pathology, Moti Lal Nehru Medical College, University of Allahabad, 16/2, Lowther Road, Allahabad-211002, India.
Dental Faculty-Periodontology, University of Bergen, Arstadveien 17, 5009 Bergen.
Cancer Genomics Proteomics. 2004 Jul-Aug;1(4):283-294. Epub 2004 Jul 1.
The global increase in incidence and mortality, as well as the poor prognosis of oral squamous cell carcinoma (OSCC), has intensified efforts in the field of prevention and early detection of this disfiguring disease. Prevalence of OSCC is common in areas with high consumption of tobacco products and alcohol. Understanding the carcinogenicity of this cancer, using innovative techniques in genomic and proteomic analysis, is the main focus of current research in OSCC, and the hunt for potential molecular biomarkers is accelerating. Although recent advances in preventive, diagnostic and therapeutic techniques related to OSCC have yielded novel molecular targets, partially uncovered signal pathway dominance and advanced early neoplasia detection, the number of deaths attributed to this disease exceeds that reported for cervical cancer, malignant melanoma and Hodgkin's disease. Application of advanced molecular biology techniques for classification, profiling of tumour tissues and/or identification of potential markers of OSCCs is on the rise. This review aims at outlining the available knowledge on epidemiology, aetiology, molecular biology, and genomics and proteomics in relation to OSCCs.
口腔鳞状细胞癌（OSCC）的全球发病率和死亡率上升，且预后不佳，这加大了对这种毁容性疾病的预防和早期检测领域的研究力度。OSCC在烟草制品和酒精消费量高的地区很常见。利用基因组和蛋白质组分析中的创新技术来了解这种癌症的致癌性，是当前OSCC研究的主要重点，寻找潜在分子生物标志物的工作正在加速。尽管与OSCC相关的预防、诊断和治疗技术最近取得了进展，产生了新的分子靶点，部分揭示了信号通路优势并推进了早期肿瘤形成的检测，但该疾病导致的死亡人数超过了宫颈癌、恶性黑色素瘤和霍奇金病的报告死亡人数。先进分子生物学技术在OSCC分类、肿瘤组织分析和/或潜在标志物鉴定方面的应用正在增加。本综述旨在概述与OSCC相关的流行病学、病因学、分子生物学、基因组学和蛋白质组学的现有知识。
