Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Arch Physiol Biochem. 2021 Oct;127(5):453-461. doi: 10.1080/13813455.2019.1650069. Epub 2019 Aug 9.
Oxidative stress has a major role in the nephrosis. In the present study, the effects of hydroalcoholic extract of (ZM) and carvacrol (CAR) were evaluated on the renal damage induced by adriamycin (ADR). The animals accidentally divided into four groups including: Control, ADR, ZM + ADR and CAR + ADR. The renal tissue, urine, and blood samples subjected to biochemical markers and histopathological evaluation. ADR significantly decreased glomerular filtration rate (GFR) while escalated urine protein excretion as well as protein clearance ( < .01 to < .001). Also, ADR significantly reduced the antioxidants and boosted the malondialdehyde (MDA) compared to the control ( < .05 to < .01). In groups treated by ZM and CAR, GFR, and antioxidants significantly increased, whereas urine protein excretion and MDA decreased ( < .05 to < .001). ZM and CAR induced an improvement in ADR-induced renal damage by improving renal function as well as antioxidant activity.
氧化应激在肾病中起着重要作用。在本研究中，评估了水醇提取物（ZM）和香芹酚（CAR）对阿霉素（ADR）诱导的肾脏损伤的影响。动物意外地分为四组：对照组、ADR 组、ZM+ADR 组和 CAR+ADR 组。对肾组织、尿液和血液样本进行生化标志物和组织病理学评估。ADR 显著降低肾小球滤过率（GFR），同时增加尿蛋白排泄和蛋白清除率（<0.01 至<0.001）。此外，与对照组相比，ADR 显著降低了抗氧化剂水平，增加了丙二醛（MDA）（<0.05 至<0.01）。ZM 和 CAR 治疗组的 GFR 和抗氧化剂显著增加，而尿蛋白排泄和 MDA 减少（<0.05 至<0.001）。ZM 和 CAR 通过改善肾功能和抗氧化活性，改善了 ADR 诱导的肾脏损伤。
