Chung Wai-Yeung, Liu Song-Yan, Gao Jing-Chun, Jiang Yi-Jing, Zhang Jing, Qu Shan-Shan, Zhang Ji-Ping, Tan Xiao-Long, Chen Jun-Qi, Wang Sheng-Xu
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province; School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Neural Regen Res. 2019 Dec;14(12):2126-2131. doi: 10.4103/1673-5374.262590.
The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers (three men and four women; 50-70 years old) received International Standard Scalp Acupuncture at MS5 (the mid-sagittal line between Baihui (DU20) and Qianding (DU21)), the left MS6 (line joining Sishencong (EX-HN1) and Xuanli (GB6)), and the left MS7 (line joining DU20 and Qubin (GB7)). After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus (42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions. The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016 (approval No. 2016ks043).
针刺影响中枢神经系统的具体机制尚不清楚。在国际标准头皮针系统中，针刺部位位于头顶中线、顶颞前斜线和顶颞后斜线。我们进行了一项单臂前瞻性临床试验，7名健康老年志愿者（3名男性和4名女性；年龄50 - 70岁）在MS5（百会（督脉20）和前顶（督脉21）之间的矢状中线）、左侧MS6（四神聪（经外奇穴HN1）和悬厘（胆经6）的连线）以及左侧MS7（督脉20和曲鬓（胆经7）的连线）接受国际标准头皮针治疗。针刺后，静息态功能磁共振成像显示各区域低频波动分数振幅和局部一致性发生变化，双侧前扣带回、左侧额内侧回、缘上回、右侧额中回和额下回局部一致性显著增强。基于右侧额中回（42, 51, 9）种子区的功能连接在双侧额上内侧回降低。我们的数据初步表明，健康老年受试者接受国际标准头皮针治疗可特异性增强大脑网络调节系统中参与认知和执行的脑区与周围相邻脑区之间的相关性。该研究于2016年7月18日获得中国吉林大学中日联谊医院伦理委员会批准（批准号2016ks043）。
