Song Guo-Ping, Yao Ting-Ting, Wang Dan, Li Yue-Hua
Institute of Diagnostic and Interventional Radiology, Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, Shanghai, China.
Neural Regen Res. 2019 Dec;14(12):2141-2146. doi: 10.4103/1673-5374.262594.
Diffusion kurtosis imaging can be used to assess pathophysiological changes in tissue structure and to diagnose central nervous system diseases. However, its sensitivity in assessing hippocampal differences between patients with Alzheimer's disease and those with amnestic mild cognitive impairment has not been characterized. Here, we examined 20 individuals with Alzheimer's disease (11 men and 9 women, mean 73.2 ± 4.49 years), 20 with amnestic mild cognitive impairment (10 men and 10 women, mean 71.55 ± 4.77 years), and 20 normal controls (11 men and 9 women, mean 70.45 ± 5.04 years). We conducted diffusion kurtosis imaging, using a 3.0 T magnetic resonance scanner, to compare hippocampal differences among the three groups. The results demonstrated that the right hippocampal volume and bilateral mean kurtosis were remarkably smaller in individuals with Alzheimer's disease compared with those with amnestic mild cognitive impairment and normal controls. Further, the mean kurtosis was lower in the amnestic mild cognitive impairment group compared with the normal control group. The mean diffusion in the left hippocampus was lower in the Alzheimer's disease group than in the amnestic mild cognitive impairment and normal control groups, while the mean diffusion in the right hippocampus was lower in the Alzheimer's disease group than in the normal control group. Fractional anisotropy was similar among the three groups. These results verify that bilateral mean kurtosis and mean diffusion are sensitive to the diagnosis of Alzheimer's disease and amnestic mild cognitive impairment. This study was approved by the Ethics Review Board of Affiliated Sixth People's Hospital of Shanghai Jiao Tong University, China on May 4, 2010 (approval No. 2010(C)-6).
扩散峰度成像可用于评估组织结构的病理生理变化及诊断中枢神经系统疾病。然而，其在评估阿尔茨海默病患者与遗忘型轻度认知障碍患者海马差异方面的敏感性尚未得到明确。在此，我们对20例阿尔茨海默病患者（11名男性和9名女性，平均年龄73.2±4.49岁）、20例遗忘型轻度认知障碍患者（10名男性和10名女性，平均年龄71.55±4.77岁）和20名正常对照者（11名男性和9名女性，平均年龄70.45±5.04岁）进行了研究。我们使用3.0T磁共振扫描仪进行扩散峰度成像，以比较三组之间的海马差异。结果表明，与遗忘型轻度认知障碍患者和正常对照者相比，阿尔茨海默病患者的右侧海马体积和双侧平均峰度明显更小。此外，遗忘型轻度认知障碍组的平均峰度低于正常对照组。阿尔茨海默病组左侧海马的平均扩散率低于遗忘型轻度认知障碍组和正常对照组，而阿尔茨海默病组右侧海马的平均扩散率低于正常对照组。三组之间的分数各向异性相似。这些结果证实双侧平均峰度和平均扩散率对阿尔茨海默病和遗忘型轻度认知障碍的诊断具有敏感性。本研究于2010年5月4日获得中国上海交通大学附属第六人民医院伦理审查委员会批准（批准号：2010(C)-6）。
