Y.A. Martins, C.A.E.F. Cardinali, M.I. Ravanelli, and K. Brunaldi are with the Department of Physiological Sciences, State University of Maringa, Maringa, Parana, Brazil.
Nutr Rev. 2020 Feb 1;78(2):115-133. doi: 10.1093/nutrit/nuz033.
Recent findings have suggested a high prevalence of vitamin D deficiency or insufficiency in fibromyalgia (FM) patients despite the lack of clinical and pathophysiological evidence.
A systematic review was conducted to examine the association between vitamin D status and FM, including the effect of vitamin D supplementation.
PubMed, LILACS, Scopus, SciELO, Cochrane, and EMBASE were searched, from January 2000 to July 2018, using the descriptors "Fibromyalgia" and "Vitamin D."
Trials including FM patients in whom vitamin D levels were assessed were eligible for inclusion.
Data comprised age, gender, country, aims, bias, diagnosis criteria, cutoff point, and status of vitamin D, together with FM symptoms and vitamin D supplementation protocol.
A total of 26 articles were selected. Most of the studies were found to present unreliable control groups and small samples. Experimental data on vitamin D supplementation indicated improvement in certain FM symptoms.
Prevalence of hypovitaminosis D in the FM population and the cause-effect relationship were inconclusive. Nevertheless, vitamin D supplementation may be considered as a co-adjuvant in FM therapy.
尽管缺乏临床和病理生理学证据，但最近的研究结果表明，纤维肌痛（FM）患者的维生素 D 缺乏或不足的患病率很高。
系统评价旨在检查维生素 D 状态与 FM 之间的关联，包括维生素 D 补充的效果。
从 2000 年 1 月到 2018 年 7 月，使用“纤维肌痛”和“维生素 D”的描述词，在 PubMed、LILACS、Scopus、SciELO、Cochrane 和 EMBASE 中进行了搜索。
包括评估维生素 D 水平的 FM 患者的试验有资格入选。
数据包括年龄、性别、国家、目的、偏倚、诊断标准、临界值以及维生素 D 的状况，以及 FM 症状和维生素 D 补充方案。
共选择了 26 篇文章。大多数研究发现对照组不可靠且样本量小。关于维生素 D 补充的实验数据表明，某些 FM 症状有所改善。
FM 人群中维生素 D 缺乏的流行率和因果关系尚无定论。然而，维生素 D 补充剂可被视为 FM 治疗的辅助剂。
